Anthraquinones from the Roots of <Emphasis Type="Italic">Knoxia valerianoides</Emphasis> inhibit the formation of advanced glycation end products and rat lens aldose reductase <Emphasis Type="Italic">in vitro</Emphasis> |
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Authors: | Nam Hee Yoo Dae Sik Jang Yun Mi Lee Il Ha Jeong Jung-Hee Cho Joo-Hwan Kim Jin Sook Kim |
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Institution: | 1.Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research,Korea Institute of Oriental Medicine (KIOM),Daejeon,Korea;2.Jeonnam Development Institute for Korea Traditional Medicine,Jeonnam,Korea;3.Department of Life Science,Kyungwon University,Seongnam,Korea |
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Abstract: | Eight known compounds, lucidin (1), lucidin-ω-methyl ether (2), rubiadin (3), damnacanthol (4), 1,3,6-trihydroxy-2-methoxymethylanthraquinone (5), 3,6-dihydroxy-2-hydroxymethyl-9,10-anthraquinone (6), 1,3,6-trihydroxy-2-hydroxymethyl-9,10-anthraquinone 3-O-β-primeveroside (7), and vanillic acid (8), were isolated from EtOAc- and n-BuOH-soluble fractions of the roots of Knoxia valerianoides. The structures of 1–8 were identified by analysis of spectroscopic data as well as by comparison with published values. All the isolates were subjected
to in vitro bioassays to evaluate advanced glycation end products (AGEs) formation and rat lens aldose reductase (RLAR) inhibitory activity.
Compound 5 showed the most potent inhibitory activity (IC50 = 52.72 μM) against AGEs formation. Compounds 1, 2, and 8 also showed potent inhibitory activity on AGEs formation with IC50 values of 79.28, 62.79, and 93.93 μM, respectively, compared with positive control, aminoguanidine (IC50 = 962 μM). While, compounds 1 and 5–7 showed strong inhibitory activity against RLAR with IC50 values of 3.35, 3.04, 6.39, and 2.05 μM, respectively. |
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