Ultrastructural study of iron deposition in the eccrine sweat glands of patients with iron overload |
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Authors: | V FALANGA P ZHENG R M LAVKER |
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Institution: | Hospital of the University of Pennsylvania, Department of Dermatology, Philadelphia;Duhring Laboratories, Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia |
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Abstract: | An ultrastructural study of eccrine sweat glands was carried out on three patients with iron overload (two with idiopathic haemochromatosis and one with transfusional haemosiderosis). In all three patients small electron-dense particles were seen in both eccrine sweat glands and macrophages. They appeared primarily in the clear cells of the eccrine sweat glands as membrane-bound irregularly shaped bodies, and were shown to contain iron by energy dispersive X-ray microanalysis. Iron aggregates in and around sweat glands were also seen on light microscopy. |
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