2-正丁基-5-甲酰基咪唑的合成

目的合成抗高血压药伊普沙坦的关键中间体2-正丁基-5-甲酰基咪唑。方法乙二胺与戊腈在硫粉的作用下环合得到2-正丁基咪唑啉（2），经脱氢、碘化、还原、羟甲基化、氧化、催化氢解得到目标化合物2-正丁基-5-甲酰基咪唑（1）。结果与结论目标化合物的结构经MS、^1H-NMR谱确证，优化后的合成路线，所用试剂易得、操作简单、反应条件温和，总收率为10．8％。

Synthesis of 2-butyl-5-formylimidazole

Aim To synthesize a key intermediate of eprosartan, 2-butyl-5-formylimidazole(1). Methods With ethylenediamine and valeronitrile as raw materials, 2-butyl-imidazoline (2) was synthesized in the presence of sulfur, after dehydrogenation, iodination, reduction, hydroxymethylation, oxidation, hydrogenolysis to give 2-butyl-5-formylimidazole. Results and conclusion Aimed compound was synthesized and identified by MS and ¹H-NMR. The starting materials in the synthetic route are easily available and this procedure has advantage of convenient operations and mild conditions. The total yield is 10.8%.