In Vitro Interactions between Target of Rapamycin Kinase Inhibitor and Antifungal Agents against Aspergillus Species |
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| Authors: | Lujuan Gao Xiaozhen Ding Zhun Liu Qingzhi Wu Tongxiang Zeng Yi Sun |
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| Affiliation: | aDepartment of Dermatology, Zhongshan Hospital Fudan University, Shanghai, People''s Republic of China;bDepartment of Dermatology, Jingzhou Central Hospital, Jingzhou City, Hubei Province, People''s Republic of China;cYangtze University, Jingzhou City, Hubei Province, People''s Republic of China |
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| Abstract: | In vitro interactions of INK128, a target of rapamycin (TOR) kinase inhibitor, and antifungals, including itraconazole, voriconazole, posaconazole, amphotericin B, and caspofungin, against Aspergillus spp. were assessed with the broth microdilution checkerboard technique. Our results suggested synergistic effects between INK128 and all azoles tested, against multiple Aspergillus fumigatus and Aspergillus flavus isolates. However, no synergistic effects were observed when INK128 was combined with amphotericin B or caspofungin. No antagonism was observed for any combination. |
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