胆固醇与高密度脂蛋白比值和缺血性脑卒中发病危险性的关系

目的探讨胆固醇/高密度脂蛋白比值(TC/HDL)的高低与缺血性脑卒中发病危险性之间的关系。以及这一比值与年龄增长之间的相关性。方法收集518例缺血脑卒中患者及491例非缺血性卒中对照个体的血脂情况,包括血总胆固醇(TC)、甘油甘酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)等指标,对其进行统计分析比较。结果 (1)病例组胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)与对照组无显著差异(P0.05),而高密度脂蛋白(HDL)水平显著低于对照组[(1.08±0.31)mmol/L比(1.21±0.32)mmol/L,P0.05];(2)病例组的TC/HDL比值为4.28±1.22,对照组为4.09±1.24。病例组TC/HDL比值显著高于对照组(P0.05);(3)病例组和对照组合并后按年龄分为四组,对各年龄段组的TC/HDC比值进行两两比较,组间差异无统计学意义(P0.05)。结论 HDL在缺血性脑卒中患者中明显降低,其保护因素降低可能是卒中发生的原因之一。血浆中TC/HDL比值≥4.28可能是缺血性卒中的一个独立危险因素,而且这一比值不随年龄增长而改变。

The relationship between the plasma TC/HDL and the risk of ischemic stroke

Objective To investigate the relationship between the plasma TC/HDL and the risk of ischemic stroke and the correlation between TC /HDL ratio and the age. Methods The levels of plasma total cholesterol（ TC） 、triglycerides（ TG） 、low density lipoprotein（ LDL） and high density lipoproteins（ HDL） were collected from518 patients with ischemic stroke 491 controls. Results（ 1） There were no significant difference in the level of plasma cholesterol,triglycerides,low density lipoprotein cholesterol between the two groups,but the stroke plasma HDL- C in patients with ischemic stroke was lower than that in patients without ischemic stroke.（ 2） The ratio of TC /HDL in patients with ischemic stroke was（ 4. 28 ± 1. 22）,which was significantly higher than that in the control group（ 4. 09 ± 1. 24）.（ 3） After the combination of the two groups,the patients were divided into 4 groups according to the age. There were no significant difference in the plasma TC /HDL ratio between different age groups Conclusions The decreased HDL level may be involved in the attack of ischemic stroke. The vaule of plasma TC /HDL radio above 4. 28 may be an independent risk factor for ischemic stroke,which do not change with age.