Hemoperfusion and DNA Synthesis in the Rat Liver Part II: The Effect of Hemoperfusion on DNA Synthesis in the Rat Liver Undergoing Compensatory Hyperplasia after Partial Hepatectomy |
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Authors: | Calvin J. Ryan James M. Courtney Leslie H. Blumgart |
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Affiliation: | Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, Du Cane Road., London W12 OHS, England, U.K.;Bioengineering Unit, University of Strathclyde, Glasgow, U.K. |
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Abstract: | An investigation has been made into whether hemoperfusion over activated charcoal effects the rate of DNA synthesis in the rat liver undergoing compensatory hyperplasia. Hemoperfusion was performed in the unrestrained and conscious rat, thus minimizing any possible effects of stress and eliminating exposure to anesthetic agents. The results demonstrate that hemoperfusion over Norit RBX1 charcoal does not influence the liver to undergo compensatory hyperplasia following partial hepatectomy when hemoperfusion is performed immediately after hepatic injury, and that liver mass, function, and fat content consequent upon partial hepatectomy are also not influenced. |
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Keywords: | hemoperfusion rat activated charcoal partial hepatectomy DNA synthesis |
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