| 慢性锰中毒动物模型的建立 |
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| 引用本文： | 杨辉,黄世文. 慢性锰中毒动物模型的建立[J]. 广西医学, 2011, 33(5): 519-522 |
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| 作者姓名： | 杨辉 黄世文 |
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| 作者单位： | 1. 广西壮族自治区分析测试研究中心,南宁市,530021
2. 广西壮族自治区职业病防治研究院,南宁市,530021 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 目的 建立一种简便、实用、稳定、可靠的慢性锰中毒动物模型.方法 SD大鼠腹腔每天注射15 mg/kg MnCl2·4H2O 12周,同时设立对照组,观察锥体外系组织(纹状体)组织学变化及大鼠肌张力等指标改变;并对脑组织取样测定锰( Mn2+)、多巴胺水平变化.结果 染毒结束后SD大鼠出现确定的肌张力增高、平衡失调;电镜...
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| 关 键 词： | 慢性锰中毒 动物模型 大鼠 |
Establishment of Animal Model of Chronic Manganism |
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| YANG Hui,HUANG Shi-wen. Establishment of Animal Model of Chronic Manganism[J]. Guangxi Medical Journal, 2011, 33(5): 519-522 |
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| Authors: | YANG Hui HUANG Shi-wen |
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| Affiliation: | 1 Guangxi Analysis and Test Center,Nanning 530021,China;2 Guangxi Occupational Disease Research Institute,Nanning 530021,China) |
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| Abstract: | Objective To establish a simple,practical,stable and reliable animal model of chronic manganism.Methods SD rats were treated with MnCl2·4H2O（15 mg/kg）by intraperitoneal injection every day for 12 weeks,at the same time,normal control group was set up.The histological changes in extrapyramidal system（striatum）and muscular tension of SD rats were observed;the levels of Mn（Mn2＋）and dopamine in SD rats brain tissues were detected.Results The muscular tension increased and a certain balance unsteadiness was found in SD rats after exposure,nerve cells degeneration and nerve fibre demyelination were observed under electronic microscope;the content of Mn increased in brain of SD rat,the content of Mn2＋ in extrapyramidal system increased more than four times,dopamine synthesis decreased,which conformed to chronic manganism.Conclusion This method can be used to establish an ideal model for chronic manganism. |
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| Keywords: | Chronic manganism Animal model Rat |
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