药物、毒物和食物相关急性肾衰竭的临床研究

目的 了解药物、毒物和食物相关急性肾衰竭(ARF)的病因构成、预后,为药物、毒物和食物相关ARF的早期防治提供理论依据.方法 对药物、毒物和食物相关ARF患者进行回顾性分析,并与其他病因ARF进行比较,总结其病因及其转归的特点.结果 药物、毒物和食物相关ARF患者119例,占同期ARF的19.5%;患者男女比例为2.0...

A Clinical Research of Food, Drug and Poison-related Acute Renal Failure

Objective To investigate the etiology, prognosis, risk factors of death among acute renal failure （ARF） patients from drug,food and poison,providing a theory basis for the prevention and treatment of ARF induced by drug,food and poison. Methods The clinical data of ARF patients induced by drug,food and poison were analyzed retrospectively, compared the those data with other etiology, and summarized features, clinical characteristic and prognosis of ARF. Results 119 ARF patients induced by drug,food and poison, which accounted for 19.48% of total amount of ARF admitted during the same time. The sex ratio of male to ferule was 2.0 ： 1.0, the age was （40.96 ＋ 18.87 ） years. The main causes of ARF from drug were antibiotics （33. 68% ）, mannitol （20. 00% ）, traditional Chinese medicine （ 17.89% ）, non-steroidal anti-inflammatory drugs （NSA/Ds） （6. 32% ）, chemotherapeutics （5.26%）. The main causes of ARF induced by poison were organophosphorus compounds （25.00%）,fish gall bladder poisoning （20. 83% ）, bee venom （ 16.67% ）. The mortality of ARF induced by drug,food and poison lower than that of other etiology（7.56% vs 16.7% ）. Multiple logistic regression analysis showed MODS was the risk factor of irreversible renal failure in ARF induced by drug, food and poison. Conclusion ARF induced by drug, food and toxic is not uncommon in ARF, those with MODS may be poor prognosis and high fatality ratio, and these vatients should be treated actively.