| 白癜风患者血清及皮肤组织液sICAM-1和IL-12的水平 |
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| 引用本文： | 陈建华,曾静,钟文俊. 白癜风患者血清及皮肤组织液sICAM-1和IL-12的水平[J]. 郧阳医学院学报, 2008, 27(3) |
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| 作者姓名： | 陈建华 曾静 钟文俊 |
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| 作者单位： | [1]郧阳医学院附属太和医院体检中心,湖北十堰442000 [2]郧阳医学院附属太和医院皮肤科,湖北十堰442000 |
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| 摘 要： | 目的:探讨可溶性细胞间黏附分子-1(sICAM-1)和白细胞介素-12(IL-12)在稳定期白癜风患者血清及皮肤组织液中的变化。方法:将32例稳定期白癜风患者根据皮损分布分为寻常型与节段型,分别进行负压吸疱移植治疗,收集白斑及正常皮肤的疱液,同时抽取外周血5mL,用ELISA法检测皮肤组织液及血清中sICAM-1及IL-12的水平。结果:寻常型白癜风患者局部白斑处皮肤组织液sICAM-1及IL-12水平较非白斑处显著增高;而节段型白癜风白斑与非白斑处皮肤组织液sICAM-1及IL-12水平无显著性差异。稳定期白癜风患者血清sICAM-1及IL-12水平与对照组相比,均无显著性差异。结论:寻常型稳定期白癜风患者局部白斑皮肤微环境处于免疫异常状态,sICAM-1及IL-12可能参与了其发病的某一环节。
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| 关 键 词： | 白癜风 细胞间黏附分子-1 白细胞介素-12 |
Levels of Intercellular Adhesion Molecule-1and Interleukin-12 in Serum and Skin Tissue Fluid of Vitiligo Patients in Stable Stage |
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| CHEN Jian-hua,ZENG Jing,ZHONG Wen-jun. Levels of Intercellular Adhesion Molecule-1and Interleukin-12 in Serum and Skin Tissue Fluid of Vitiligo Patients in Stable Stage[J]. Journal of Yunyang Medical College, 2008, 27(3) |
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| Authors: | CHEN Jian-hua ZENG Jing ZHONG Wen-jun |
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| Affiliation: | CHEN Jian-hua1,ZENG Jing2,ZHONG Wen-jun2 (Department of Dermatology,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,Chian) |
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| Abstract: | Objective To measure sICAM-1 and IL-12 between vitiliginous and non-vitiliginous patches in patients with stable vitiligo,and to compare them in serum with normal controls. Methods Thirty-two vitiligo patients in stable stage were divided into common type vitiligo and segmental type vitiligo. Suction blister fluid and peripheral blood were drawn and collected,and the enzyme-linked immunosorbent assay was used to determine the levels of sICAM-1 and IL-12 in serum and skin tissue fluid. Result The levels of s... |
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| Keywords: | Vitiligo Intercellular adhesion molecule-1 Interleukin-12 |
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