Mapping of a new RFLP marker RN1 (DXS369) close to the fragile site FRAXA on Xq27-q28. |
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| Authors: | B A Oostra D F Majoor-Krakauer J O van Hemel E Bakker D F Callen M Schmidt B A van Oost |
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| Institution: | Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands. |
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| Abstract: | A new polymorphic DNA marker RN1, defining locus DXS369, was recently isolated. Using different somatic cell hybrids, RN1 was mapped between markers 4D-8 and U6.2. We have narrowed the localization of RN1 to the region between 4D-8 and FRAXA by genetic mapping in fragile X fra(X)] families. Combined with information from other reports, the following order of loci on Xq27-q28 is suggested: cen-F9-(DXS105-DXS152)-DXS98-DXS369-FRAXA- DXS304-(DXS52-DXS15-F8)-tel. The locus DXS369 is closely linked to FRAXA, with a peak lodscore of 18.5 at a recombination fraction of 0.05. Therefore, RN1 is a useful probe for carrier detection and prenatal diagnosis in fra(X) families. |
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