Helicobacter pylori and gastric carcinoma |
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Authors: | R.J.L.F. LOFFIELD I. WILLEMS J.A. FLENDRIG J.W. ARENDS |
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Affiliation: | Department of Internal Medicine University Hospital Maastricht, The Netherlands. |
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Abstract: | A retrospective study was performed on gastric carcinomas to establish the prevalence of Helicobacter pylori infection in gastric epithelium adjacent to the tumour. A total of 105 carcinomas were studied. The overall prevalence of Helicobacter pylori infection was 59%. The prevalence in different age cohorts from patients with gastric carcinoma was compared with that in patients suffering from non-ulcer dyspepsia and, based on serological testing, with that in healthy blood donors. The presence of Helicobacter pylori in cancer patients aged 41-50 and 51-60 was significantly higher than in blood donors. No difference was seen in comparison with non-ulcer dyspepsia patients. The presence of Helicobacter pylori showed an inverse correlation with the extent of intestinal metaplasia. The intestinal type of carcinoma was associated with a higher bacterial load than the diffuse type. These data suggest that the presence of Helicobacter pylori in gastric mucosa could play a role in the pathogenesis of gastric carcinoma, especially in the young age group. |
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Keywords: | Helicobacter pylori gastritis gastric carcinoma intestinal metaplasia intestinal type gastric carcinoma |
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