| 白刺链霉菌15-4-2中的抗MRSA活性成分研究 |
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| 引用本文： | 郁蕾,戴好富,曾艳波,李小娜,梅文莉,曾会才. 白刺链霉菌15-4-2中的抗MRSA活性成分研究[J]. 中国抗生素杂志, 2012, 37(2): 94-97 |
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| 作者姓名： | 郁蕾 戴好富 曾艳波 李小娜 梅文莉 曾会才 |
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| 作者单位： | 中国热带农业科学院热带生物技术研究所,海南省黎药资源天然产物研究与利用重点实验室,海口571101;海口市热带天然产物研究与利用重点实验室,海口571101 |
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| 基金项目： | 国家973计划前期研究专项 |
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| 摘 要： | 目的研究白刺链霉菌(Streptomyces albospinus)15-4-2发酵液中的抗耐甲氧西林金葡菌(MRSA)活性成分。方法通过活性跟踪,采用柱层析等方法对白刺链霉菌15-4-2的次生代谢产物进行分离纯化。采用光谱分析对活性成分进行结构解析。结果分离鉴定了7个化合物,其结构分别为N-(2-羟基-1-(4-甲氧基苯基)乙基)乙酰胺(1)、2-(4-甲氧基苯基)-2-(丙胺基)乙醇(2)、cytoxazone(3)、对羟基苯甲酸(4)、(2S,3R)-3-羟基-2-甲基丁酸(5)、对甲基苯酚(6)和1,4-二甲氧基苯(7)。结论抗菌活性测试结果表明化合物1、3、4、5和6具有抗耐甲氧西林金黄色葡萄球菌(MRSA)活性。其中,1、3、4和5的抗耐甲氧西林金黄色葡萄球菌活性为首次报道。
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| 关 键 词： | 白刺链霉菌15-4-2 化学成分 结构鉴定 抗菌活性 |
Anti-MRSA constituents from the Streptomyces albospinus 15-4-2 |
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| Yu Lei , Dai Hao-fu , Zeng Yan-bo , Li Xiao-na , Mei Wen-li , Zeng Hui-cai. Anti-MRSA constituents from the Streptomyces albospinus 15-4-2[J]. Chinese Journal of Antibiotics, 2012, 37(2): 94-97 |
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| Authors: | Yu Lei Dai Hao-fu Zeng Yan-bo Li Xiao-na Mei Wen-li Zeng Hui-cai |
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| Affiliation: | 1,2(1 Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101;2 Haikou Key Laboratory for Research and Development of Tropical Natural Products,Haikou 571101) |
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| Abstract: | Objective To study the antibacterial constituents from the fermentation broth of Streptomyces albospinus 15-4-2.Methods Bioassay-guided column chromatography was used to separate the antibacterial components from the fermentation broth of Streptomyces albospinus 15-4-2.Results Seven compounds were isolated and identified as N-(2-hydroxy-1-(4-methoxyphenyl)ethyl)acetamide(1),2-(4-methoxyphenyl)-2-(propylamino)ethanol(2),cytoxazone(3),p-hydroxybenzoic acid(4),(2S,3R)-3-hydroxy-2-methylbutanoic acid(5),p-methylphenol(6) and p-dimethoxy benzene(7).Conclusion The antibacterial assay exhibited that compounds 1,3,4,5 and 6 showed inhibitory effects on methicillin-resistant Staphylococcus aureus(MRSA),and it was the first time to report the anti-MRSA effects of 1,3,4 and 5. |
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| Keywords: | Streptomyces albospinus 15-4-2 Chemical constituent Structural identification Antibacterial activity |
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