Portal vein thrombosis during antineoplastic chemotherapy in children: report of five cases and review of the literature |
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| Authors: | Brisse H Orbach D Lassau N Servois V Doz F Debray D Helfre S Hartmann O Neuenschwander S |
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| Affiliation: | aImaging Department, Institut Curie, 26 rue d’Ulm, 75005 Paris, France;bDepartment of Paediatric Oncology, Institut Curie, 26 rue d’Ulm, 75005 Paris, France;cImaging Department, Ultrasonography Unit, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France;dDepartment of Paediatric Hepatology, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France;eDepartment of Radiotherapy, Institut Curie, 26 rue d’Ulm, 75005 Paris, France;fDepartment of Paediatric Oncology, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France |
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| Abstract: | We report five paediatric cases of portal vein thrombosis (PVT) occurring during chemotherapy, observed in two institutions over an 8-year time period. These children aged 2.5–15 years were treated for Burkitt’s lymphoma, Ewing’s tumour, small cell bone tumour or medulloblastoma. PVT was diagnosed on colour Doppler ultrasonography (US). In four patients, thrombosis occurred 2–45 days after severe hepatic veno-occlusive disease (HVOD) secondary to intensive chemotherapy containing busulfan. In one case, PVT occurred in the absence of HVOD in a patient with pre-existing periportal lymphomatous infiltration. Four patients experienced persistent portal hypertension, which resulted in death in one. PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD. |
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| Keywords: | Portal vein Liver Child Antineoplastic agents Alkylating agents Haematopoietic cell transplantation Thromboembolism Hepatic veno-occlusive disease Ultrasonography |
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