多巴胺D4基因48bp可变重复序列多态性与注意缺陷多动障碍相关性的Meta分析

目的 进一步探讨多巴胺D4受体(DRD4)基因第三外显子48 bp可变重复序列(VNTR)多态性与注意缺陷多动障碍(ADHD)儿童青少年的相关情况。方法 通过中国知网(CNKI)、万方、维普、中国生物医学文献数据库(CBM)、PubMed、Cochrane Library、EBSCO、Ovid、Springer数据库,检索国内外关于DRD4基因第3外显子48 bp VNTR多态性与儿童ADHD关联性的病例对照研究,采用Meta分析综合定量分析纳入文献。结果 20篇文献共纳入3 658例ADHD患者和6 272例对照,Meta分析结果提示在总人群中4R、7R和长片段ADHD组与对照组相比差异均有统计学意义,其他片断ADHD组与对照组相比差异均无统计学意义。亚洲人群中各种重复片段的ADHD组与对照组相比差异均无统计学意义。非亚洲人群中4R、7R、短片断和长片段(＞4R)ADHD组与对照组相比差异均有统计学意义,其余重复片段差异均无统计学意义。结论 Meta分析显示总人群DRD4 48 bp 4R、7R、长片段(＞4R)与ADHD间有相关性;非亚洲人群DRD4 48 bp4R、7R、短片段、长片段(＞4R)与ADHD间有相关性;亚洲人群48 bp VNTR多态性与ADHD间均未显示有相关性。

Association of the 48 bp variable number of tandem repeat polymorphism of dopamine D4 receptor gene with attention deficit hyperactivity disorder:a Meta-analysis.

Objective To explore the association of the 48 bp variable number of tandem repeat(VNTR) polymorphism at exon 3 of dopamine D4 receptor (DRD4) gene with attention deficit hyperactivity disorder (ADHD). Methods The Chinese and English references about the association between 48 bp VNTR polymorphism of DRD4 gene and ADHD were retrieved through Chinese National Knowledge Infrastructure (CNKI),Wanfang,Weipu,Chinese Biomedical Database( CBM),PubMed,Cochrane Library,EBSCO,Ovid,Springer databases,until October 30,2015.A Meta-analysis was used to systematically analyze the literatures. Results A total of 20 studies were included in the final Meta-analysis,enrolling a total of 3 658 ADHD cases and 6 272 controls.The Meta-analysis showed that the frequencies of DRD4 gene 48 bp 4 repeat (4R),7 repeat (7R) and long repeat had statistical differences between ADHD group and the control group in the global group;the frequencies of DRD4 gene 48 bp had not statistical difference between ADHD group and the control group in the Asia group ;the frequencies of DRD4 gene 48 bp 4R,7R,short repeat and long repeat had statistical differences in the non-Asia group. Conclusions The Meta-analysis revealed that the DRD4 48 bp 4R,7R and long repeat have association with ADHD in the global group;The DRD4 48 bp 4R,7R,short repeat and long repeat have association with ADHD in the global group in non-Asia group.There is no statistical difference between ADHD group and the control group in the Asia group.