肺炎支原体对支气管哮喘患儿肺功能的影响

目的 研究肺炎支原体感染对哮喘患儿肺功能的影响,从而对临床诊治及预后评估提供客观依据。方法 回顾性分析2013年10月-2015年10月潍坊医学院诊治的哮喘患儿临床资料,其中在急性期治疗1周后行肺功能检查的患儿共576例,分为阳性组(哮喘合并肺炎支原体感染组)144例,阴性组(哮喘不合并肺炎支原体感染者)432例,对两组患儿肺通气功能检查各指标进行统计学分析。结果 1)阴性组与阳性组组间对比肺通气功能各项指标对比,用力肺活量(FVC)及第一秒用力呼气容积/用力肺活量(FEV1%)两项指标,阴性组与阳性组之间比较,差异无统计学意义(P>0.05);阳性组FEV1、PEF和MMEF 25-75、PEF25、PEF50各值均低于阴性组,差异具有统计学意义(P<0.05),且以MMEF 25-75下降为主。2)阳性组组内对比根据支原体抗体滴度,将阳性组患儿再次分为高滴度组与低滴度组,将两组肺通气功能检查各项指标进行比较,差异无统计学意义(P>0.05)。结论 感染肺炎支原体可降低哮喘患儿肺功能,且以加重小气道阻塞性病变为主,因此日后对合并支原体感染的哮喘患儿应引起高度重视。

Effect of mycoplasma pneumonia infection on pulmonary function in children with bronchial asthma.

Objective To explore the effect of mycoplasma pneumonia infection on pulmonary function in children with bronchial asthma,and provide objective basis for clinical treatment and prognosis assessment. Methods The clinical data of asthmatic children who were diagnosed and treated in our hospital from October 2013 to October 2015 were retrospectively analyzed.576 cases who have received pulmonary function test in the acute phase of treatment for one week were divided into two groups:positive group (asthma with mycoplasma pneumoniae infection group,144 cases)and negative group (asthma without mycoplasma pneumoniae infection,432 cases).Then the pulmonary ventilation function check indexes were analyzed by statistical software. Results 1)Comparison between negative group and positive group:about the lung ventilation function of two groups,positive group's forced vital capacity (FVC) was higher than that of negative group,the first second forced expiratory volume/forced vital capacity (FEV1 %) was lower than that of the negative group,and there was no statistically significant difference between them;Besides,first second forced expiratory volume (FEV1),peak expiratory flow (PEF) and maximal expiratory flow (MMEF) 25-75,PEF25,PEF50 in positive group were lower than those in negative group,and there were statistically significant differences (P<0.05),giving priority to MMEF 25-75.2)Comparision within positive group:children in the positive group were divide into the high titer group and the low titer group according to mycoplasma pneumoniae antibody titer.And there was no statistically significant difference between the two groups about the lung ventilation function (P>0.05). Conclusion Mycoplasma pneumoniae infection can reduce pulmonary function in children with asthma,giving priority to increasing the small airway obstructive pathological changes,so it is necessary to pay more attention to asthma children with mycoplasma pneumonia infection.