妊娠期梅毒的诊疗进展

梅毒螺旋体能通过胎盘引起胎儿宫内感染,造成流产、死产、早产或分娩胎传梅毒儿.死胎和新生儿死亡是最严重的妊娠不良结局.因此,围产期应常规开展妊娠期梅毒血清学的产前筛查工作.在梅毒高流行区或高危人群,尚需在孕28周和分娩时作2次血清学检查.一旦确诊,应尽早、足量、正规给予青霉素治疗,并加强新生儿随防.孕期有效的青霉素治疗,将降低围产期死亡率及胎传梅毒的发生.

Advances in the diagnosis and treatment of syphilis in pregnant women

Treponema pallidum in pregnant women could pass through the placenta and cause abortion, fetal death, premature birth, and congenital syphilis. Neonatal death and stillbirth are the most severe adverse pregnancy outcomes. So it is especially important to routinely screen syphilis in pregnant women during perinatal period. In regions with high prevalence of syphilis and among high risk population, syphilis should be screened twice in the first 28 weeks of pregnancy and at the time of birth. Once the diagnosis of pregnant syphilis is confirmed, early treatment with regular and adequate doses of penicillin as well as a close follow up of neonates are warranted. Effective treatment with penicillin during pregnancy may lead to a decrease in perinatai mortality and incidence of congenital syphilis.