| 免疫抑制剂的研究新进展 |
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| 引用本文： | 刘魏,何广卫,吴强,徐云根.免疫抑制剂的研究新进展[J].药学进展,2010,34(5):193-201. |
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| 作者姓名： | 刘魏 何广卫 吴强 徐云根 |
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| 作者单位： | 1. 中国药科大学药物化学教研室,江苏,南京210009
2. 合肥医工医药有限公司,安徽,合肥230088 |
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| 摘 要： | 目前临床上使用的免疫抑制剂存在多种不良反应，而鞘氨醇-1-磷酸（S1P）、淋巴细胞特异性酪氨酸蛋白激酶（Lck）、Janus激酶3（JAK3）和哺乳类动物雷帕霉素靶蛋白（mTOR）等新的免疫抑制作用靶点的出现为开发活性高、副作用小的新型免疫抑制剂提供了新途径。综述S1P受体激动剂以及Lck、JAK3和mTOR抑制剂等4类免疫抑制剂的最新研究进展，探讨其衍生物的构效关系。
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| 关 键 词： | 免疫抑制剂 鞘氨醇-1-磷酸 淋巴细胞特异性酪氨酸蛋白激酶 Janus激酶3 哺乳类动物雷帕霉素靶蛋白 |
Recent Advances in Research of Immunosuppressive Drugs |
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| LIU Wei,HE Guang-wei,WU Qiang,XU Yun-gen.Recent Advances in Research of Immunosuppressive Drugs[J].Progress in Pharmaceutical Sciences,2010,34(5):193-201. |
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| Authors: | LIU Wei HE Guang-wei WU Qiang XU Yun-gen |
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| Institution: | LIU Wei1,HE Guang-wei2,WU Qiang2,XU Yun-gen1 (1.Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China,2.Hefei Medical Engineering Pharmaceutical Co.,Ltd.,Hefei 230088,China ) |
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| Abstract: | The advances in research of some novel immunodepressants,including sphingosine-1-phosphate(S1P) agonist,inhibitors of lymphocyte specific protein tyrosine kinase (Lck),Janus kinase 3 (JAK3) and mammalian target of rapamycin (mTOR) was reviewed,and their structure-activity relationship was investigated.The development of novel immunodepressants with a higher activity and less side effects which targeted on S1P1,Lck,JAK3 and mTOR have provided a hopeful settlement for the issues of adverse reaction exsiting w... |
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| Keywords: | immunodepressant S1P Lck JAK3 mTOR |
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