An electromyographic analysis of the effect of levodopa on the response time of healthy subjects |
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| Authors: | Thierry Hasbroucq Christophe Tandonnet Joëlle Micallef-Roll Olivier Blin Camille-Aimé Possamaï |
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| Affiliation: | (1) Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique et Université de Provence, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France,;(2) Institut de Neurosciences Physiologiques et Cognitives, Centre National de la Recherche Scientifique et Université de la Méditerranée, Centre Hospitalier de la Timone, Marseille, France,;(3) Laboratoire d'Analyse de la Performance Motrice Humaine, Université de Poitiers, Maison des Sciences de l'Homme, Poitiers, France, |
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| Abstract: | Abstract
Rationale. Recently, we have shown that oral absorption of levodopa shortens reaction time (RT), measured as the interval between the
response signal and the onset of voluntary electromyographic (EMG) activity. The motor time (MT) interval that elapses from
the EMG activity to the mechanical response was not analysed.
Objective. The purpose of the present study was to analyse the effect of the dose of levodopa administrated in our previous study on
the MT. Eight healthy adults (aged 21–28, mean=25), performed a two-choice visual RT task after oral absorption of a single
dose of levodopa (200 mg) or a placebo (randomized, double-blind, cross-over design).
Results. Like RT, MT was shorter under levodopa than under placebo. Statistical analyses demonstrated that this effect was present
for all deciles of the RT and MT distributions.
Conclusion. Levodopa shortens not only RT but also MT, which points at the implication of the dopaminergic system in both premotor and
motor processes.
Electronic Publication |
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| Keywords: | Levodopa Healthy subjects Reaction time Motor time |
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