大肠癌P~(53)蛋白测定与临床生物学意义的相关研究

目的　探讨P53 蛋白表达与大肠癌的关系及临床生物学意义。方法　采用免疫组织化学技术对 32例大肠癌组织及 16例正常大肠组织中的p53 蛋白的表达进行观察和比较。结果　P53 在正常大肠组织中表达阴性 ,P53 蛋白在大肠癌组织中表达阳性率为 5 3 13%。P53 蛋白在大肠癌组织中的表达与患者的性别、年龄、肿瘤大小、部位、大体分型、浸润深度、组织学类型、Ducks’分期及局部淋巴结转移无明显关系 (P >0 .0 5 )。P53 蛋白表达与大肠癌伴肝转移相关 (P <0 .0 5 )。结论　P53 蛋白在大肠癌组织中表达阳性 ,尤以伴肝转移者为著。p53 蛋白过度表达提示预后不良。

Expression and Clinical Significance of P53 Protein in Colorectal Cancer

Objective To investigate the clinial significance of P53 proteinexpression in patients with colorectal cancer. Method Using immunohistochemistry staining, We observed P53 protein expression in 32 cases of colorectal cancer tissues and 16 cases of normal colorectal tissue. Result P53 protein was negative in normal colorectal tissue. P53 protein was positive in 17(53.13%)cases of colorectal cancer. The expression of P53 protein had no apprent relation to the patients' sex, age, area of invasion, Duck's classfication, size of tumors, type of histopathology, lymphonodus metastases, etc(P>0.05). The over expression of P53 protein was closely associated with the liver metastases(P<0.05). Conclusion P53 protein was positive in colorectal cancer especially in patients with liver metastases. The abnormal expression of P53 protien was associated with the poor prognosis.