| 熔融高速搅拌法制备双氯芬酸钠缓释胶囊的研究 |
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| 引用本文： | 孟祥磊,王洪光. 熔融高速搅拌法制备双氯芬酸钠缓释胶囊的研究[J]. 中国现代应用药学, 2009, 26(8): 641-644 |
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| 作者姓名： | 孟祥磊 王洪光 |
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| 作者单位： | 青岛科技大学药学院，山东 青岛 266042 |
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| 摘 要： | 目的研究熔融高速搅拌法制备双氯芬酸钠缓释胶囊及其体外释药行为。方法采用KJZ-10型熔融高速搅拌制粒机制备含药微丸,以微丸体外释放度为指标,考察处方工艺因素对微丸体外释放度的影响,通过释放度曲线药动力学拟合确定微丸缓释机制。结果双氯芬酸钠微丸体外释放行为符合Higuchi方程Y=35.43t1/2-16.1523（r=0.9988）,释药机制主要是骨架溶蚀和扩散释放。结论该技术制备的双氯芬酸钠缓释微丸具有较好的释药性能及良好的缓释效果。
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| 关 键 词： | 熔融法 缓释胶囊 骨架溶蚀 双氯芬酸钠 |
| 收稿时间： | 1900-01-01 |
Studies on Preparation of Diclofenac Sodium Sustained-release Capsules by High-shear Melt Agglomeration |
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| MENG Xianglei,WANG Hongguang. Studies on Preparation of Diclofenac Sodium Sustained-release Capsules by High-shear Melt Agglomeration[J]. The Chinese Journal of Modern Applied Pharmacy, 2009, 26(8): 641-644 |
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| Authors: | MENG Xianglei WANG Hongguang |
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| Affiliation: | Department of Pharmacy, Qingdao University of Science and Technology, Qingdao 266042, China |
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| Abstract: | OBJECTIVE Solid dispersion technique was used for enhancing the dissolution rate of Andrographolide (Andro). METHODS Andro PVP solid dispersions which contain different proportion Tween-80 were prepared by solvent method. The composing of solid dispersion |
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| Keywords: | andrographolide solid dispersion PVPk30 Tween-80 orthogonal design |
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