益气化瘀法对置铜宫内节育器家兔子宫内膜形态学的影响

目的:探讨益气化瘀法治疗铜宫内节育器(Cu-IUD)所致子宫异常出血的作用机理.方法:以吲哚美辛作对照,观察宫环止血灵对置Cu-IUD家兔子宫内膜表浅微血管的变化、血栓形成及螺旋动脉的形态学改变.结果:置Cu-IUD模型组上皮脱落坏死,有大量炎性细胞浸润,宫腔中见多量组织碎片,炎性细胞及渗出液,内膜下小血管部分扩张、充血;间质较疏松水肿,可见较多炎性细胞浸润;高倍视野下子宫内膜表浅微血管总数增多.宫环止血灵各剂量组内膜上皮轻度损伤,内膜炎性细胞较少,偶见小血管扩张、充血,间质较致密,炎性细胞少,其形态变化与对照组吲哚美辛相似.结论:益气化瘀法能减少置Cu-IUD家兔子宫内膜的炎性细胞及炎性渗出,对子宫内膜的损伤具有修复作用,说明益气化瘀法对上环后子宫异常出血具有良好的治疗作用.

Effects of Endometrial Hismorphology of Cu-IUD Wearing Rabbits by Treating with Nourishing qi and Eliminating stasiS Method

Objective To explore the mechanism of nourishing qi and eliminating stasis method to treat endometrorrhagia caused by Cu-IUD.Methods In constrast with Indomethacin,we investigated the effects of endometrial superficial microvessel,thrombosis and spiral artery of Cu-IUD wearing rabbits treating with nourishing qi and eliminating stasis method by olympus light microscope.Results In Cu-IUD wearing rabbits contrast group endometrial epithelia were shed,necrosis and infiltrated with a lot of inflammatory cells.Much constitution fragments,inflammatory cells and exudate were observed in uterine cavity.Endometrial small vessels were dilatalted and hyperemia.Interstitial was a little rarefaction,edema and infiltrated with a lot of inflammatory cells.The sum of endometrial superficial microvessel was increased.The hismorphologic change of each group of nourishing qi and eliminating stasis method was similar to the Indomethacin group:endometrial epithelia was minor injury with less inflammatory cells,endometrial small vessels were occasionlly dilatalted and hyperemia,interstitial was a little tight with less inflammatory ceils.Conclusion Treated with nourishing qi and eliminating stasis method can decrease the inflammatory cells and exudation of endometrium and repair the damage of endometrium,wich indicate that endometrorrhagia caused by Cu-IUD can be cured effectively with nourishing qi and eliminating stasis method.