Role of metalloproteinases in platelet function |
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| Authors: | Santos-Martínez María José Medina Carlos Jurasz Paul Radomski Marek W |
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| Affiliation: | School of Pharmacy and Pharmaceutical Sciences Trinity College Dublin, Ireland. |
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| Abstract: | Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These proteins exert several effects regulating platelet functions such as agonist-stimulated platelet adhesion and aggregation, tumour cell-induced platelet aggregation and platelet-leukocyte aggregation. In this review, mechanisms of MMPs, TIMPs and ADAMs on platelets are discussed. |
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| Keywords: | MMPs, matrix metalloproteinases MT-MMPs, membrane-type matrix metalloproteinases TIMPs, tissue inhibitors of matrix metalloporteinases ADAMs, disintegrin metalloproteinases ECM, extracellular matrix NO, nitric oxide PGI2, prostacyclin VWF, Von Willebrand factor PI, phosphoinositide PLC, phospholipase C PKC, protein kinase C PI3-K, phosphatidylinositol 3-kinase egr-1, early growth response-1 MAP, mitogen-activated protein TXA2, thromboxane A2 TNF-alpha, tumour necrosis factor alpha TACE, TNF-alpha converting enzyme UL, ultra-large TTP, thrombotic thrombocytopenic purpura TCIPA, tumour cell-induced platelet aggregation PLA, Platelet−leukocyte aggregation PAR, proteinase-activated receptor ACS, acute coronary syndrome. |
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