风湿热患儿血清可溶性肿瘤坏死因子受体I的变化

目的 :了解肿瘤坏死因子系统在急性风湿热 (ARF)中的作用。方法 :用ELISA法对ARF、风湿性心脏病风湿活跃期 (活动期组 ) ,风湿性心脏病风湿静止期 (静止期组 )及健康人对照组血清可溶性肿瘤坏死因子受体I(sTN FRI)水平进行检测 ,并与血沉 (ESR) ,C反应蛋白 (CRP)进行相关分析。结果 :活动期组血清sTNFRI浓度为 (3 92±1 2 8)ng·ml- 1 明显高于静止期组 (1 43± 0 6 6 )ng·ml- 1 及健康人对照组 (1 0 6± 0 42 )ng·ml- 1 (均 P<0 .0 1 ) ;静止期组与健康人对照组比较 ,差异无显著性 (P >0 .0 5 )。活动期组血清sTNFRI改变与CRP呈正相关 (r =0 82 4 ,P <0 .0 0 1 )。结论 :ARF患儿血清sTNFRI水平可作为判断风湿活跃的一项实验室指标。

Changes of serum soluble tumor necrosis factor receptor I in patients with rheumatic fever

Objective To study the changes and the effects of soluble tumor necrosis factor receptor I (sTNFR I) in patients with rheumatic fever, and to find out the laboratorial marker of clinic activity in patients with rheumatic fever. Methods The serum concentrations of sTNFR I in 16 patients with ARF, 16 patients with chronic inactive rheumatic heart disease (CRHD) and 15 healthy controls were measured by methods of ELISA and the relationship between sTNFR I and ESR or CRP were studied. Results The sTNFR I serum concentrations in patients with ARF (3.92±1.28) ng.ml -1 were significantly higher than those with CRHD (1.43±0.66)ng.ml -1 and healthy controls (1.06±0.42)ng.ml -1 (all P<0.01). The serum concentrations of sTNFR I in patients with CRHD were almost the same with those in healthy controls (P>0.05); Their positive correlation was significantly observed between sTNFR I and CRP(P<0.001), and wasn’t observed between sTNFR I and ESR. Conclusion The Patients with ARF have high serum levels of sTNFR I. It may be used as the laboratorial marker in the clinic assessment of acivity in patients with rheumatic fever.