| 创伤后癫痫大鼠模型海马突触素的变化 |
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| 引用本文： | 姚源蓉,孙圣刚,童萼塘. 创伤后癫痫大鼠模型海马突触素的变化[J]. 华夏医学, 2003, 16(4): 450-452 |
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| 作者姓名： | 姚源蓉 孙圣刚 童萼塘 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院神经科,武汉,430022 |
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| 摘 要： | 目的：探讨突触素在创伤后癫痫海马结构的改变及意义。方法：应用铁离子杏仁体注射制作创伤后癫痫模型，用免疫组织化学和计算机图像分析技术定量分析海马各区突触素在不同时间的改变。结果：模型组损伤侧及对侧齿状回分子层内带突触素免疫反应产物密度逐渐增加，15d达高峰，一直延续到30d。结论：齿状回突触素含量的变化可能是创伤后癫痫发生的分子病理学基础。
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| 关 键 词： | 突触素 癫痫 离子 免疫组织化学 海马 |
| 文章编号： | 1008-2409(2003)04-0450-03 |
| 修稿时间： | 2003-03-10 |
Changes of Synaptophysin in Hippocampus in Post-Traumatic Epilepsy Rat Model |
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| YAO Yuan-rong,SUN Sheng-gang,TONG E-tang//. Changes of Synaptophysin in Hippocampus in Post-Traumatic Epilepsy Rat Model[J]. Acta Medicinae Sinica, 2003, 16(4): 450-452 |
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| Authors: | YAO Yuan-rong SUN Sheng-gang TONG E-tang// |
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| Affiliation: | YAO Yuan-rong,SUN Sheng-gang,TONG E-tang//Department of Neurology,Union Hospital,Tongji Medical School,Huazhong University of Science and Technology,Wuhan 430022,China |
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| Abstract: | Objective:To study the significance of the changes of hippocampus synaptophysin in post-traumatic epilepsy rat model Methods:Rats were given an amygdaloid body injection of ferric chloride and the changes of synaptophysin at different time after injection were detected quantitatively with immunohistochemistry and computerized image analysis Results:The synaptophysin positive immunoreactive product in the inner molecular layer in the dentate gyrus was increased bilaterally over time in hippocampus,the strongest staining was on 15 days,and the increasing of positive immunoreactive product up to 30 days after iron injetion Conclusion:The changes of synaptophysin in the dentate gyrus may be the molecular and pathological elementt of post-traumatic epilepsy |
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| Keywords: | synaptophysin epilepsy iron limmunohistochemisty hippocampus |
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