| 类风湿关节炎骨代谢变化及清热解毒方药的干预作用 |
| |
| 引用本文： | 郭明阳,罗勇,刘德芳,张俊,郭玲林,贠明东,晏蛟.类风湿关节炎骨代谢变化及清热解毒方药的干预作用[J].中国中医药信息杂志,2011,18(12):14-16. |
| |
| 作者姓名： | 郭明阳 罗勇 刘德芳 张俊 郭玲林 贠明东 晏蛟 |
| |
| 作者单位： | 中国人民解放军成都军区总医院,四川成都,610083 |
| |
| 摘 要： | 目的观察活动性类风湿关节炎（RA）骨代谢变化特点及清热解毒方药的干预作用。方法将105例活动性RA患者随机分为治疗组（54例）和对照组（51例），另选50例年龄、性别相匹配的健康体检者作为健康组。对照组以甲氨蝶呤（MTX）为基本药物，治疗组在此基础上复给予清解热毒方药—速效热痹饮，2组均治疗3个月。观察患者治疗前后疼痛关节数及程度、肿胀关节数及程度、晨僵时间、休息痛和医生对目前病．情的评估，并检查红细胞沉降率（ESR）、C反应蛋白（CRP）、骨特异性碱性磷酸酶（BAP）和抗酒石酸酸性磷酸酶（TRACP5b）。结果RA患者治疗前BAP和TRACP5b均较健康组增高（P〈0．01），治疗后治疗组BAP和TRACP5b明显下降（P〈0．05），对照组虽也呈下降趋势，但无统计学意义（P〉0．05）。治疗后2组BAP和TRACP5b差异具有统计学意义（P〈0．05）。结论活动性RA骨形成和骨吸收均表现为亢进，但以骨吸收为主。清热解毒方药能降低BAP和TRACP5b等骨代谢指标，表现为对骨破坏的抑制作用。
|
| 关 键 词： | 类风湿关节炎 清热解毒 骨特异性碱性磷酸酶 抗酒石酸酸性磷酸酶 |
Bone Metabolism of Rheumatoid Arthritis and Intervention of Heat-clearing and Toxicity-reliving Drug |
| |
| GUO Ming-yang
,
LUO Yong
,
LIU De-fang
,
ZHANG Jun
,
GUO Ling-lin
,
YUAN Ming-dong
,
YAN Jiao.Bone Metabolism of Rheumatoid Arthritis and Intervention of Heat-clearing and Toxicity-reliving Drug[J].Chinese Journal of Information on Traditional Chinese Medicine,2011,18(12):14-16. |
| |
| Authors: | GUO Ming-yang LUO Yong LIU De-fang ZHANG Jun GUO Ling-lin YUAN Ming-dong YAN Jiao |
| |
| Institution: | GUO Ming-yang,LUO Yong,LIU De-fang,ZHANG Jun,GUO Ling-lin,YUAN Ming-dong,YAN Jiao(Chengdu Military Hospital,Chengdu 610083,China) |
| |
| Abstract: | Objective To observe the characteristics of bone metabolism of activity rheumatoid arthritis(RA) and the intervention of heat-clearing and toxicity-reliving drug.Methods One hundred and five cases of activity RA was randomly divided into treatment group(n=54) and control group(n=51).In addition,50 healthy controls matched in age and sex were as healthy group.The control group used MTX as basic medicine,while the treatment group was given heat-clearing and toxicity-reliving herbs-quick acting potion for heat... |
| |
| Keywords: | rheumatoid arthritis heat-clearing and toxicity-reliving BAP TRACP5b |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
