| 难溶性药物水飞蓟宾固体分散体的制备及评价(英文) |
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| 引用本文： | 马燕,李卫中,古锦辉. 难溶性药物水飞蓟宾固体分散体的制备及评价(英文)[J]. 中国药学, 2011, 20(6): 604-608. DOI: 10.5246/jcps.2011.06.078 |
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| 作者姓名： | 马燕 李卫中 古锦辉 |
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| 作者单位： | 广州中医药大学中药学院;慧谷医药有限公司; |
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| 摘 要： | 采用溶剂法制备水飞蓟宾的PVP K30固体分散体以提高其溶解度和溶出速率;通过平衡溶解度、溶出速率、DSC和FTIR等方法验证和定性分析制备的固体分散体。水飞蓟宾的固体分散体与原料药及物理混合物相比,改善了药物的溶解度和溶出速率。DSC曲线显示水飞蓟宾的吸热峰消失,表明水飞蓟宾以无定形物分散于载体材料中;FTIR的研究结果表明水飞蓟宾的羟基和PVP K30的羰基发生了反应。固体分散技术可应用于难溶性药物以改善其体外溶出及进一步的体内吸收。
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| 关 键 词： | 水飞蓟宾 固体分散体 PVP K30 DSC FTIR |
Preparation and evaluation of the solid dispersions of poorly soluble silybin |
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| Yan Ma,Wei-Zhong Li,Jin-Hui Gu .School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou ,China .Huigu Pharmaceutical Co.Ltd.,Guangzhou ,China. Preparation and evaluation of the solid dispersions of poorly soluble silybin[J]. Journal of Chinese Pharmaceutical Sciences, 2011, 20(6): 604-608. DOI: 10.5246/jcps.2011.06.078 |
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| Authors: | Yan Ma Wei-Zhong Li Jin-Hui Gu .School of Chinese Materia Medica Guangzhou University of Chinese Medicine Guangzhou China .Huigu Pharmaceutical Co.Ltd. Guangzhou China |
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| Affiliation: | Yan Ma~(1*),Wei-Zhong Li~2,Jin-Hui Gu~1 1.School of Chinese Materia Medica,Guangzhou University of Chinese Medicine,Guangzhou 510006,China 2.Huigu Pharmaceutical Co.Ltd.,Guangzhou 510610,China |
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| Abstract: | To improve its solubility and dissolution,solid dispersions of silybin in PVP K30 were prepared by the conventional solvent evaporation method and characterized by equilibrium solubility and dissolution studies,differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy(FTIR).Silybin solid dispersions showed increased solubility and rates of dissolution compared with pure drug and corresponding physical mixtures of silybin and PVP K30.Thermograms of various solid dispersions did not ... |
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| Keywords: | Silybin Solid dispersions PVP K30 DSC FTIR |
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