| 加味建瓴汤对原发性高血压患者胰岛素抵抗及血清白细胞介素-6水平的影响 |
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| 引用本文： | 张宁,孙久林,董致郅,陈少军. 加味建瓴汤对原发性高血压患者胰岛素抵抗及血清白细胞介素-6水平的影响[J]. 中国中医药信息杂志, 2011, 18(12): 19-20,26 |
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| 作者姓名： | 张宁 孙久林 董致郅 陈少军 |
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| 作者单位： | 北京市怀柔区中医医院,北京,101400 |
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| 摘 要： | 目的观察加味建瓴汤对原发性高血压患者胰岛素抵抗及血清白细胞介素-6（IL-6）水平的影响，并探讨其可能的作用机制。方法选择符合纳入标准的原发性高血压伴胰岛素抵抗患者60例，采用随机、单盲、对照试验设计分为治疗组和对照组各30例。对照组给予依那普利10mg／次，每日1次口服，治疗组在西药治疗基础上予加味建瓴汤150mL／次，每日2次口服，疗程为3周。观察2组患者治疗前后空腹血糖、血浆胰岛素水平、中医症状、血清IL-6水平变化，并计算胰岛素敏感指数。结果治疗组较对照组经治疗后空腹血糖、空腹胰岛素水平明显降低，胰岛素敏感指数明显改善，血清IL-6水平明显下降（P〈0．01或P〈0．05）；治疗组中医症状疗效明显优于对照组（P〈0．01）。结论加味建瓴汤能显著降低血糖、血浆胰岛素水平，改善一临床症状和减轻胰岛素抵抗。降低血清IL-6水平，抑制炎症反应，可能是其改善胰岛素抵抗的机制之一。
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| 关 键 词： | 加味建瓴汤 原发性高血压 胰岛素抵抗 白细胞介素-6 中西医结合疗法 |
Effect of Jiawei Jianling Tang on Insulin Resistance and Serum Interleukin-6 of Essential Hypertension Patients |
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| ZHANG Ning , SUN Jiu-lin , DONG Zhi-zhi , CHEN Shao-jun. Effect of Jiawei Jianling Tang on Insulin Resistance and Serum Interleukin-6 of Essential Hypertension Patients[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2011, 18(12): 19-20,26 |
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| Authors: | ZHANG Ning SUN Jiu-lin DONG Zhi-zhi CHEN Shao-jun |
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| Affiliation: | ZHANG Ning,SUN Jiu-lin,DONG Zhi-zhi,CHEN Shao-jun(TCM Hospital of Huairou District,Beijing 101400,China) |
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| Abstract: | Objective To study the curative effect of Jiawei Jianling Tang on insulin resistence and the interleukin-6(IL-6) level of essential hypertension(EH) patients,and investigate its action mechanism.Methods Sixty EH patients according with the diagnosis criteria were divided into two groups at random,single-blind,controlled trial.Each group had 30 patients.The control group were treated with enalaprilat(10 mg,Qd),while the treatment group was treated with Jiawei Jianling Tang(150 mL,Bid) on the basis of western... |
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| Keywords: | Jiawei Jianling Tang essential hypertension insulin resistance interleukin-6 integrated therapy of traditional Chinese and western medicine |
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