| 怡心饮对糖尿病心肌病大鼠心肌病理和结缔组织生长因子的影响 |
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| 引用本文： | 王海颖,陆敏,鲍君璐,陈德兴.怡心饮对糖尿病心肌病大鼠心肌病理和结缔组织生长因子的影响[J].中国中医药信息杂志,2011,18(12):36-38. |
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| 作者姓名： | 王海颖 陆敏 鲍君璐 陈德兴 |
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| 作者单位： | 上海中医药大学,上海,201203 |
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| 基金项目： | 上海市教委方剂学重点学科建设项目子项目(z09011-03) |
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| 摘 要： | 目的观察怡心饮对糖尿病心肌病大鼠心肌病理和结缔组织生长因子表达的影响。方法运用高糖高脂饲料＋链脲佐菌素（STZ）腹腔注射建立大鼠2型糖尿病心肌病模型，并将其分为正常组、模型组、生脉饮对照组及怡心饮高、低剂量组。给予相应药物灌胃治疗8周，观察糖尿病心肌病大鼠的心脏病理及血脂，血清脂联素、结缔组织生长因子的变化，分析其减轻大鼠心肌病变的机理。结果怡心饮能明显改善STZ大鼠胰岛素抵抗，减少大鼠血清结缔组织生长因子，改善脂联素表达，减轻糖尿病心肌病理改变。结论怡心饮对糖尿病大鼠心肌病变有一定的改善作用，其作用机制可能与改善胰岛素抵抗和降低结缔组织生长因子的表达有关。
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| 关 键 词： | 怡心饮 心肌超微结构 结缔组织生长因子 糖尿病 大鼠 |
Effect of Yixinyin on Cardiac Pathological Change and Connective Tissue Growth Factor of Diabetic Rats |
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| WANG Hai-ying
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LU Min
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BAO Jun-lu
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CHEN De-xing.Effect of Yixinyin on Cardiac Pathological Change and Connective Tissue Growth Factor of Diabetic Rats[J].Chinese Journal of Information on Traditional Chinese Medicine,2011,18(12):36-38. |
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| Authors: | WANG Hai-ying LU Min BAO Jun-lu CHEN De-xing |
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| Institution: | WANG Hai-ying,LU Min,BAO Jun-lu,CHEN De-xing(Shanghai University of TCM,Shanghai 201203,China) |
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| Abstract: | Objective To investigate the influence of Yixinyin to the cardiac pathological change and connective tissue growth factor(CTGF) of diabetes mellitus(DM) rats and its protective mechanism.Methods DM rats were induced with STZ and high glucose-lipids animal feeds.Rats were randomly divided into normal group,model group,Shengmaiyin group,Yixinyin high-dose and low-dose group,and given corresponding treatment for 8 weeks.The changes of cardiac pathological change,adiponectin and CTGF were observed.Results Yixin... |
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| Keywords: | Yixinyin myocardial ultrastructure CTGF diabetes mellitus rats |
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