| 雷帕霉素靶分子在糖尿病肾病发病机制中的作用 |
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| 引用本文： | 王德光,李学旺. 雷帕霉素靶分子在糖尿病肾病发病机制中的作用[J]. 国外医学:内科学分册, 2007, 34(7): 375-378 |
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| 作者姓名： | 王德光 李学旺 |
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| 作者单位： | [1]安徽医科大学附属省立医院肾内科,安徽合肥230001 [2]北京协和医院肾内科,北京100730 |
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| 摘 要： | 哺乳动物雷帕霉素靶分子位于胰岛素/胰岛素样生长因子通路的下游,同时接受营养信号和能量信号,参与细胞、器官和生物体肥胖的调控,引起胰岛素抵抗,促进血管内皮细胞生长因子的表达,可能在2型糖尿病及糖尿病肾病的发生发展中起重要的作用.
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| 关 键 词： | 雷帕霉素靶分子 2型糖尿病 糖尿病肾病 胰岛素抵抗 血管内皮细胞生长因子 |
| 文章编号： | 1004-2369（2007）07-0375-04 |
| 修稿时间： | 2006-11-062007-02-10 |
The role of mammalian target of rapamycin in the pathogenesis of diabetic nephropathy |
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| WANG De-guang,LI Xue-wang. The role of mammalian target of rapamycin in the pathogenesis of diabetic nephropathy[J]. Foreign Medical Sciences(Section of Internal Medicine), 2007, 34(7): 375-378 |
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| Authors: | WANG De-guang LI Xue-wang |
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| Affiliation: | 1 Department of Nephrology, Anhui provincial hospital, Anhui Medical University, Hefei 230001 ; 2 Department of Nephrology, Peking Union Medical College Hospital, Beijing 100730, China |
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| Abstract: | The mamalian target of rapamycin(mTOR)plays a central role in the regulation of cell growth.mTOR receives input from insulin/insulin-like growth factors and nutrients,to stiumlate protein synthesis by phosphorylating key translation factors such as ribosomal S6 kinase and eukaryote initiation factor 4E binding protein 1.Hyperactivation of mTOR is associated with obesity,insulin resistance and increased vascular endothelial growth factor expression.Here we will discuss the emerging evidence for a functional relationship between the mTOR signaling pathway and diabetic nephropathy in type 2 diabetes. |
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| Keywords: | Mammalian target of rapamycin Type 2 diabetes Diabetic nephropathy Insulin resistance Vascular endothelial growth factor |
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