氧化修饰低密度脂蛋白及内皮素-1水平与消化性溃疡

为探讨低密度脂蛋白的氧化修饰程度及内皮素分泌情况在胃及十二指肠溃疡发病中的作用及其机理，用单克隆抗体酶联免疫吸附法和放射免疫分析均相竞争法分别测定了血浆中氧化修饰低密度脂蛋白和内皮素－１的含量。结果：胃及十二指肠溃疡患者血浆中的氧化修饰低密度脂蛋白水平分别为（０．５２±０．０９）ｍｇ／Ｌ和（０．６７±０．０９）ｍｇ／Ｌ，均较正常人（０．３２±０．０７）ｍｇ／Ｌ呈显著升高（Ｐ＜０．０１），内皮素－１水平在胃及十二指肠溃疡时分别为（１０．２±２．３）ｎｇ／Ｌ和（１３．１±２．８）ｎｇ／Ｌ，也较正常人（６．０±１．３）ｎｇ／Ｌ明显地增高（Ｐ＜０．０１）；两项指标在胃溃疡患者均明显地低于十二指肠溃疡患者（Ｐ＜０．０５）；且两指标的总体水平均与溃疡直径呈明显正相关（Ｐ＜０．０５）。提示氧化修饰低密度脂蛋白和内皮素－１可能参与了溃疡的形成过程，并有可能是造成溃疡的重要因素。

Levels of Oxidatively Modified Low Density Lipoprotein (ox LDL) and Endothelin(ET) in Digestive Ulcer Patients

To investigate the role of degree of LDL being oxidatively modified and the secretion of endothelin in the forming of gastric ulcer and duodenal ulcer. The level of plasma ox LDL was tested by McAb ELISA, and the concentration of plasma ET was examined by RIA. The concentration of plasma ox LDL in gastric ulcer patients and duodenal ulcer patients were 0.524± 0.087 mg/L and 0.669±0.094 mg/L, respectively, significantly highter than the controls ( 0.316 ±0.069 mg/L, P <0.01). The level of ET were 10.2±2.3 ng/L and 13.1± 2.8 ng/L , respectively, also significantly higher than the controls (6.0±1.3 ng/L, P <0.01), Both the two indexes were positively related to the diameter of the ulcer (r ox LDL =0.4374, r ET = 0.4795 , P <0.05). Hint ox LDL and ET may contribute to the processofulcer forming and probably be important factor of producing ulcer.