Zolmitriptan, a 5-HT1B/1D receptor agonist for the acute oral treatment of migraine: a multicentre, dose-range finding study |
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Authors: | Carl Dahlöf Hans-Christoph Diener Peter J Goadsby Hélène Massiou Jes Olesen Jean Schoenen Marcia Wilkinson Ruth M Sweet Ken B Klein |
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Institution: | Gothenburg Migraine Clinic, Gothenburg, Sweden;Klinik und Poliklink für Neurologie, Essen University, Essen, Germany;Department of Neurology, Institute of Neurology, Queen Square, London, UK;Service de Neurologie, Hôspital St. Antonie, Paris, France;Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Copenhagen, Denmark;Department of Neurology, University of Liége, CHR Citadelle, Liége, Belgium;City of London Migraine Clinic, London, UK;Glaxo Wellcome, Stockley Park West Uxbridge, Middlesex;International Drug Development Consulting, Bainbridge Island WA USA |
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Abstract: | Zolmitriptan is a selective 5-HT1B/1D receptor agonist for acute oral imgraine theraphy. This randomized, placebo|controlled, parallel-grup study investigated the efficacy and tolerability of oral zolmitriptan (5, 10, 15 and 20 mg) in the tretment of single acute migraine attacks. Of 1181 patients randomized, 840 were evaluable for the primary efficacy analysis. Headache response rates (a reduction in headache intensity from severe or moderate at baseline to mild or no pain at 2 hours post-treatment) were similaracross the zolmitriptan dose groups (66%, 71%, 69% and 77% for 5 mg, 10 mg, 15 mg and 20 mg, respectively) and were significantly higher than that for placebo (19%; all groups P < 0.001). A headache response was reponse was reposted at 1 hour by 40-50% of zolmitriptan recipients (16% placebo). At 2 hours post dose,39-47% of zolmitriptan-treated patients were pain-free, compared with 1% of placebo recipients. Headache recurrence occurred in 21-29% (upper 95% CI 37.1) of zolmitriptan-treated patients and in 65% (95% CI 38.3, 85.8) of placebo recipients. Zolmitriptan was well tolerated at each dose. The most commonly reported adverse events were asthenia, dizziness, paraesthesia and feelings of heaviness. Mostadverse events were of mildor moderate intensity and were efficacy and tolerability profile, the dose response data suggest that lower doses would also offer significant efficacy. |
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Keywords: | zolmitriptan 5HT1B/1D receptor agonist migraine dose-range finding |
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