Cognitive deficits in aged rats correlate with levels of L-arginine, not with nNOS expression or 3,4-DAP-evoked transmitter release in the frontoparietal cortex. |
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| Authors: | Jean-Christophe Cassel Theresa Schweizer Anelise Lazaris Rainer Kn?rle Anja Birthelmer Ute G?dtel-Armbrust Ulrich F?rstermann Rolf Jackisch |
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| Institution: | 1. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Hansastrasse 9A, D-79104 Freiburg, Germany;2. LN2C, UMR 7521, CNRS/Université Louis Pasteur, IFR Neurosciences 37, 12 rue Goethe, F-67000 Strasbourg, France;3. Pharmakologisches Institut der Johannes Gutenberg Universität, Obere Zahlbacher Strasse 67, D-55131 Mainz, Germany;1. Department of Neurosurgery, Hospital Quiron, Murcia, Spain;2. Molecular Imaging Unit, CIMES-General Foundation of the University of Malaga, Malaga, Spain;3. Department of Neurosurgery, Carlos Haya University Hospital, Malaga, Spain;1. Key Laboratory of Child Development and Learning Science of Ministry of Education of China, School of Biological Sciences and Medical Engineering, Southeast University, China;2. School of Public Health, Southeast University, China;3. Division of Child Care, Suzhou Municipal Hospital, China;1. Department of Occupational and Environmental Health Science, School of Public Health, Peking University, Beijing 100191, China;2. Department of Occupational and Environmental Health Science, School of Public Health, Baotou Medical College, Baotou, Inner Mongolia Autonomous Region 014030, China;3. Editorial Department of Chinese Journal of Preventive Medicine, Chinese Medical Association, Beijing 100710, China;4. Department of Clinical Laboratory, Third Hospital of Peking University, Beijing 100191, China;1. Department of Biomedical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA;2. Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA;3. Department of Pediatrics, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA;1. Department of Optometry and Vision Science, University of Auckland, New Zealand;2. New Zealand National Eye Centre, University of Auckland, New Zealand;3. School of Medical Sciences, University of Auckland, New Zealand;1. Department of Normal Physiology and Biophysics, Yaroslavl State Medical Academy, Yaroslavl, Russia;2. Department of Human Anatomy, Yaroslavl State Medical Academy, Yaroslavl, Russia |
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| Abstract: | Aging is associated with altered neurotransmitter function in the brain. In this study, we measured release parameters for acetylcholine (ACh), norepinephrine and serotonin in the frontoparietal cortex of young and aged rats. We also determined cortical amino acid concentrations and nitric oxide (NO) synthase function. Prior to sacrifice, the rats had been tested for Morris water-maze performance. In aged, compared with young rats, we observed a reduction in both uptake of choline and acetylcholine release. Serotonin release and L-arginine concentrations (a precursor of NO) showed an aging-related increase; however, L-citrulline/L-arginine ratios were decreased in aged rats. Moreover, while most age-related changes in transmitter release or neurochemical markers were not related to the learning performance, L-arginine concentrations were positively correlated to cognitive deficits. NO synthase concentrations were not affected by aging. It is suggested that events related to L-arginine-to-L-citrulline/NO metabolism in the frontoparietal cortex may take part in age-related cognitive deficits. |
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