莨菪类药物对大鼠脑,心肌血流量和心指数的影响

采用放射性生物微球法观察了莨菪类药物(HD)对大鼠脑血流量(CBF)、心肌血流量(MBF)和心指数(C1)的影响.结果表明HD明显增加CBF和MBF。减小CI.本文三种药物增加大脑半球 CBF作用随剂量增加而增强,Ani10～40 mg·kg~(-1)iv增加26～73％;东莨菪碱(Sco)1.25～5mg·kg~(-1)iv增加17～38％;阿托品(Atr)2.5～10mg·kg~(-1)iv增加17～64％,HD增加MBF作用远较增加CBF作用强.Ani 10～20 mg·kg~(-1)iv增加128～198％;但40 mg·kg~(-1)iv作用明显减弱;Sco 1.25～5mg·kg~(-1)iv增加5l～116％;Atr 5～10 mg·kg~(-1)iv增加113～137％,三药均可明显减小CI。

Influence of hebane drugs on cerebral and myocardial blood flow and cardie index in rats

With chromium radioisotopes (51Cr) using the radioactive biomicrosphere assay labeling frog erythrocytes, the influence of hebane drugs (HD) on the cerebral blood flow (CBF), myocardial blood flow (MBF) and cardiac index (CI) of rats was studied. The results demonstrated that HD increased CBF and MBF but decreased CI. Anisodamine 10-40 mg·kg-1 iv increased CBF of the hemisphere by 26-73%; scopolamine 1.25-5 mg·kg-1, by 17-38%; and atropine 2.5-10 mg·kg-1, by 17-64%. Anisodamine also increased MBF but the effect reduced when the dose was larger than 20 mg·kg-1. Indeed, anisodamine 10-20 mg ·kg-1 iv increased MBF by 128-198% but 40 mg·kg-1 iv only gaves a 62% increment. Scopolamine 1.25-5·kg-1 iv increasedMBF by 51-116% and atropine 5-10 mg·kg-1 iv by 113-137%. The three drugs at various doses used in this experiment decreased CI significantly but scopolamine 5 mg·kg-1 iv decreased CI insignificantly. These results indicated that HD could change the distribution of the blood flow to ensure the blood supply for the brain and heart. This might explain why HD could be used effectively in the treatment of shock.