喹硫平治疗老年期痴呆患者行为和心理症状的临床观察

目的:探讨喹硫平治疗痴呆的行为和心理症状的疗效及不良反应。方法:64例痴呆患者随机分成两组,分别使用喹硫平和利培酮治疗8周;用AD病理行为评分表评价疗效,药物副作用量表评价不良反应。结果:(1)喹硫平组有效率为87.5%(28/32),利培酮组有效率84.4%(27/32),两组总有效率相当(P>0.05);(2)喹硫平组治疗8周后各因子分均显著降低,其中攻击行为、日夜节律紊乱、焦虑和恐惧、行为紊乱4个因子的减分具有极显著差异(P<0.01);与对照组相比在攻击行为、行为紊乱2个因子的减分的差异具有显著性(P<0.05);(3)两组不良反应率相当。结论:喹硫平和利培酮治疗痴呆的行为和心理症状的疗效相当,喹硫平的优势在于对行为障碍的疗效更加明显。

A clinical observation on curative effects and side effects of quetiapine and risperidone in the behavioral and psychological symptoms of dementia

Objective:To explore the curative effects and side effects of quetiapine in the behavioral and psychological symptoms of dementia.Methods:64 patients with dementias were randomly assigned to two groups that were treated with either quetiapine or risperidone for 8 weeks.The therapeutic response and side effects were evaluated with the behavioral pathology in Alzheimer's disease rating scale(BEHAVE-AD) and treatment emergent symptom scale(TESS).Results:(1)The total effective rates of quetiapine group and risperidone group were respectively 87.5%(28/32) and 84.4%(27/32).Statistical differences were not found between the two groups(P>0.05).(2)The scores of every factors were significant decrease,and there were significant deviation in 4 factors scores of aggressive behavior,rhythm disturbance of day and night,anxiety and horror and conduct disorder(P<0.01).The scores in 2 factors of aggressive behavior and conduct disorder were significant decrease compared with control group(P<0.05).(3)The incidence rate of side effects were no significant differences between the two groups.Conclusions: Quetiapine is equivalent to risperidone in the curative effects in the behavioral and psychological symptoms of dementia.It's the predominance for quetiapine in the treatment of behavioral disturbance.