| T细胞接种对环磷酰胺诱导的NOD鼠淋巴细胞亚群的影响 |
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| 引用本文： | 闫彩风,张志利,何国芬. T细胞接种对环磷酰胺诱导的NOD鼠淋巴细胞亚群的影响[J]. 实用口腔医学杂志, 2000, 29(4): 307-309 |
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| 作者姓名： | 闫彩风 张志利 何国芬 |
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| 作者单位： | 山西医科大学第一医院!030001 |
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| 基金项目： | 山西省归国人员基金!资助项目 (95 - 5 5 ) |
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| 摘 要： | 目的 探讨 T细胞接种 (TCV)对 1型糖尿病预防作用的机制。方法 4周龄未发病的雌性 NOD鼠用 18周龄新近发病的 NOD鼠脾细胞制得的 T细胞疫苗接种 ,检测 TCV对环磷酰胺诱导的 NOD鼠淋巴细胞亚群的变化情况。结果 TCV可以诱导宿主脾脏 CD8+ T细胞百分比升高、CD4+ / CD8+比值和 IL- 2 R+细胞下降 ,以及胸腺 CD4+、CD8+单阳性细胞百分比升高。结论 TCV可以诱导宿主产生自身免疫低反应性 ,这种作用可能与宿主脾脏和胸腺淋巴细胞亚群的变化有关。
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| 关 键 词： | T细胞接种 NOD鼠 环磷酰胺 |
| 修稿时间： | 1999-05-15 |
Effects of T cell vaccination on cyclophosphamide induced diabetes in NOD mice |
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| Yan Caifeng,Zhang Zhili,He Guofen. Effects of T cell vaccination on cyclophosphamide induced diabetes in NOD mice[J]. Journal of Practical Stomatology, 2000, 29(4): 307-309 |
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| Authors: | Yan Caifeng Zhang Zhili He Guofen |
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| Abstract: | Objective To study the prophylactic effects of T cell vaccination (TCV) on type 1 diabetes.Methods Four-week-old nondiabetic female NOD mice were vaccinated intraperitoneally with the attenuated,activated T lymphocytes isolated from the spleen of 18-week-old newly diadetic NOD mice.Measuring the T lymphocyte subset changes in spleen and thymus after TCV.Result TCV may induce the rising of percentage of CD8 T lymphocyte subset in spleen and CD4 CD8 simple-positive T lymphocyte in thymus,may induce the decreasing of percentage of IL-2R T lymphocyte and the decreasing of CD4 /CD8 rate in spleen.Conclusion TCV may decrease the autoimmune reactivity in host,that can be related with thechanges of T lymphocytes subset in spleen and thymus. |
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| Keywords: | T cell vaccination NOD mice Cyclophosphamide |
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