高血压病及其并发症患者VWF、t—PA及PAI活性的临床研究

本文以酶联免疫吸附试验定量测定高血压病及其并发症患者血浆VWF含量、以发色底物比色法测定患者血浆的t—PA和PAI活性。结果表明:高血压病患者血浆VWF量增高、t—PA活性下降、PAI活性增高;有并发症的高血压患者的上述指标变化比单纯高血压病患者更显著。本资料提示高血压病患者血液促凝活性增强,纤溶活性减弱,有并发症者变化更加明显。这将有助于探讨高血压病的发病机理,为临床上防治高血压病及其并发病提供临床资料和理论依据。

The Clinical Study on VWF, tPA and PAI in Patients with Hypertension

The plasma VWF concentration, tPA and PAI activity were examined in patients with essential hypertension. The results showed that VWF increased, tPA activity decreased and PAI activity increased in patients. These changes were more severe in patients with complications than those without complications. Our data suggested that increasing procoagulant activity and decreasing fibrinolytic activity occured in patients with essential hypertension, especially in patients with complications. This study helps explore the mechanism of hypertension, and provides clinic data and theoretic supports for therapy of the diseases.