青春期阿扑吗啡注射对大鼠潜伏抑制和高架十字迷宫行为的影响

目的 观察青春期(出生后38～51 d)阿扑吗啡注射对大鼠精神相关行为的影响.方法 以Wistar大鼠为实验对象,利用大鼠穿梭程序自动控制仪和高架十字迷宫,观察青春期(出生后38～51 d)阿扑吗啡注射对青春期和成年早期大鼠潜伏抑制和高架十字迷宫行为的影响.结果 (1)对于青春期大鼠,与生理盐水注射组动物相比前呈现组和非前呈现组分别为(38.1±18.7)次和(23.0±6.9)次],声音刺激的前呈现未能显著地降低阿扑吗啡注射组动物的条件化联合反应前呈现组和非前呈现组分别为(23.0±16.4)次和(26.7±13.5)次],即表现出潜伏抑制缺失;对于成年早期大鼠,与生理盐水注射组动物相比前呈现组和非前呈现组分别为(37.2±17.5)次和(15±6.2)次],青春期阿扑吗啡注射的大鼠同样表现出潜伏抑制缺失前呈现组和非前呈现组分别为(21.5±15.2)次和(17.2±8)次];(2)与相应的生理盐水组动物相比,青春期阿扑吗啡注射的青春期和成年早期动物的高架十字迷宫行为均差异无显著性.结论 青春期持续两周(出生后38～51 d)的慢性阿扑吗啡注射,能诱发青春期和成年早期大鼠的潜伏抑制缺失,但不影响高架十字迷宫行为.

Effects of puberty apomorphine injection on the latent inhibition and elevated plus-maze behaviors of rats

Objective To investigate the effect of puberty (PN38～51) apomorphine injection on the psychotic behaviors of rats. Methods Using computer-controlled automatic shuttle box and elevated plus-maze, the effects of puberty apomorphine injection on the latent inhibition and elevated plus-maze behaviors in puberty and early adult wistar rats were observed. Results (1) For puberty rats, compared to saline injection rats(conditioned reaction in preexposure and non-preexposure group was 38.1±18.7 and 23.0±6.9, respectively), conditioned reaction of apomorphine injection rats could not be reduced significantly by the pre-exposed sound stimulus (23.0±16.4 and 26.7±13.5, respectively), that is latent inhibition deficient.For early adult rats, compared to saline injection rats (37.2±17.5 and 15±6.2), apomorphine injection rats was also latent inhibition deficient (21.5±15.2 and 17.2±8).(2) Compared to saline injection rats, puberty apomorphine injection did not affect the elevated plus-maze behaviors of puberty and early adult rats. Conclusion Chronic puberty apomorphine injection (PN38～51) could induced the latent inhibition deficient in puberty and early adult rats, but not elevated plus-maze behaviors.