Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers |
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| Authors: | D R Rubinow R M Post D Pickar D Naber J C Ballenger P W Gold W E Bunney |
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| Institution: | 1. David R. Rubinow, M.D., Robert M. Post, M.D., David Pickar, M.D., Dieter Naber, M.D., and William E. Bunney, Jr., M.D., are in the Biological Psychiatry Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA;2. James C. Ballenger, M.D., is at the Department of Behavioral Medicine and Psychiatry, University of Virginia Medical Center, Charlottesville, VA, USA;3. Philip W. Gold, M.D., isw the Clinical Psychobiology Branch, Intramural Research Program, National Institute of Mental Health, Bethseda, M.D., USA |
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| Abstract: | We investigated the relationship between hypothalamic-pituitary-adrenal (HPA) activity, as measured by 24-hour mean urinary free cortisol (MUFC), and cerebrospinal fluid (CSF) opioid activity in patients with major affective disorder and normal volunteers. Among depressed patients, but not normal volunteers, mean 24-hour urinary cortisol values were significantly correlated with CSF opioid activity measured by radioreceptor assay, but were not significantly correlated with beta-endorphin immunoreactivity measured by radioimmunoassay. MUFC, as expected, was significantly higher in depressed patients than in normal volunteers. Mean values of CSF opioid activity and beta-endorphin immunoreactivity did not differ significantly in the two groups. The positive opioid-MUFC correlation found in the depressed group appeared to depend on patients who were cortisol hypersecretors. These data, using relatively crude measures of cortisol and opioid activity, are suggestive of a relationship between these two systems, particularly under "activated" conditions such as those observed in depression. |
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| Keywords: | Cortisol opiates depression cerebrospinal fluid |
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