| 3种细胞因子在体外对阿糖胞苷细胞毒性的影响 |
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| 引用本文： | 杨林花,张晓晖.3种细胞因子在体外对阿糖胞苷细胞毒性的影响[J].华中医学杂志,1999,23(5):201-202. |
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| 作者姓名： | 杨林花 张晓晖 |
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| 作者单位： | 山西医科大学第二附属医院血液内科 |
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| 摘 要： | 采用对碘硝基四唑（ＩＮＴ）比色法，观察了１７例急性髓性白血病（ＡＭＬ）患者和８例正常人的骨髓，在体外对阿糖胞苷的敏感性，同时分别观察了粒细胞集落刺激因子（Ｇ－ＣＳＦ），粒－巨噬细胞集落刺激因子（ＧＭ－ＣＳＦ），白细胞介素－３（ＩＬ－３）３种细胞因子对其敏感性影响。结果显示ＡＭＬ细胞与正常细胞对Ａｒａ－Ｃ敏感性存在显著差异；Ｇ－ＣＳＦ，ＧＭ－ＣＳＦ，ＩＬ－３此３种因子均能增加Ａｒａ－Ｃ对ＡＭＬ细胞的
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| 关 键 词： | 造血生长因子 急性 白血病 阿糖胞苷 体外毒性 |
In.Vitro the Effects of IL-3,G-CSF and GM-CSF on Ara-C Cytotoxicity to the Cells of Acute Myelocytic Leukemia |
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| Yang Linhua,Zhang Xiaohui.In.Vitro the Effects of IL-3,G-CSF and GM-CSF on Ara-C Cytotoxicity to the Cells of Acute Myelocytic Leukemia[J].Central China Medical Journal,1999,23(5):201-202. |
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| Authors: | Yang Linhua Zhang Xiaohui |
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| Institution: | Yang Linhua,Zhang Xiaohui. The Second Hospital of Shanxi Medical University,Taiyuan 030001 |
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| Abstract: | By using INT, the sensitivity of marrow cells to Ara-C in 17 cases of acute myelocytic leukemia(AML) and 8 normal subjects in vitro was obversed. The effects of G-CSF,GM-CSF,IL-3 on the sensitivity were simultaneously in vestigated at the same time. The results showed there was a significant difference in the sensitivity to Ara-C between the AML cells and normal cells. G-CSF, GM-CSF, IL-3 all increased the cytoxicity of Ara-C to AML cells. Heterogenicity existed in the three cytokines. However,none of the HGF significantly affected the drug cytotoxicity of Ara-C to MNC. |
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| Keywords: | hematopoietic growth factor acute myeloid leukemia cytosine arabinoside in vitro cyto-toxicity INT determination |
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