抑郁症患者静息状态的功能磁共振成像研究

目的 了解在静息状态下抑郁症患者脑区的局部一致性特点.方法 采用功能磁共振成像(fMRI)技术,检测静息状态下27例抑郁症患者(患者组)和性别、年龄、受教育程度均与患者相匹配的27名正常人(对照组)的脑功能活动,并对两组进行比较.利用局部一致性方法 分析fMRI数据,用SPM2软件进行配对t检验(P＜0.005).结果 与对照组相比,患者组双侧额中回、右额下回、右颞上回、左前扣带回、右后扣带回、右岛叶、双侧豆状核、双侧屏状核、左尾状核局部一致性显著增高(P＜0.005,未校正,体素值＞10);未显示脑区有明显的局部一致性减低.结论 抑郁症患者神经环路脑区局部在静息状态下具有很高的一致性,其局部一致性的增高可能参与了抑郁症的代偿机制.

A resting-state functional magnetic resonance imaging study in pafients with depression

Objective This study was to measure the brain regional homogeneity(ReHo)in the patients with major depressive disorders(MDD)using resting-state functional MRI.Methods The restingstate functional MRI scanning were performed in 27 patients with MDD and 27 gender-,age-,and educationmatched controls.Regional homogeneity approach was used to analyze the functional imaging data,and statistical parametric mapping 2(SPM2)was used to perform paired t-test in ReHo pictures between the patients and controls.Results In comparison with controls,the depressed patients showed significantly increased regional homogeneity in some brain regions,including bilateral middle frontal gyrus,right inferior frontal gyrus,right superior temporal gyrus,left anterior cingutate,right posterior cingutate gyrus.right insula,bilateral lenticula,bilateral claustrum,left caudate(P<0.005,uncorrected,voxel>10);but there were no brain regions showing significantly decreased regional homogeneity in patients.Conclusion The results indicate that there are very high resting-state regional homogeneity in patient with MDD,which may be involved in the compensatory mechanism of depression.