2型糖尿病患者活化血小板糖基化复合物水平与颈动脉粥样硬化的关系

探讨2型糖尿病患者血小板活化与颈动脉粥样硬化的关系。应用流式细胞仪测定118例2型糖尿病患者（其中合并颈动脉粥样硬化者73例）及25例正常对照者的血小板活化指标活化血小板糖基化复合物，同时观察活化血小板糖基化复合物，年龄，糖尿病病程，血压、血脂，血糖及肾功能与颈动脉粥样硬化的相关性。结果发现，糖尿病患者活化血小板糖基化复合物明显高于正常对照者，颈动脉粥样硬化患者活化血小板糖基化复合物，年龄，病程，血糖，糖化血红蛋白，血压及低密度脂蛋白胆固醇显著高于无颈动脉粥样硬化患者，且颈动脉狭窄程度与活化血小板糖基化复合物呈正相关。结果提示，活化血小板糖基化复合物水平增高可能是2型糖尿病患者易合并颈动脉粥样硬化的独立危险因素。

The Relationship between Glycopropean Complex of Activated Platelets and Cervical Atherosclerosis in Type 2 Diabetic Patients

Aim To investigate the relationship between glycopropean complex of activated platelets (PAC 1) and cervical atherosclerosis in type 2 diabetic patients. Methods PAC 1 were measured by FCA in 118 type 2 diabetic patients (73 with cervical atherosclerosis, 45 without cervical atherosclerosis). The correlation of PAC 1, age, diabetic courses, blood pressure, blood lipids, blood glucose and renal function with cervical atherosclerosis was evaluated. Results The level of PAC 1 in diabetic group was significantly higher than that in control group. PAC 1 in diabetic group with cervical atherosclerosis was higher than those without cervical atherosclerosis. Moreover PAC 1, age, disease course, plasma glucose, GHbA 1, blood pressure and low density lipoprotein cholesterol (LDLC) was positively correlated with cervical atherosclerosis. Conclusion The high level of PAC 1 is the independent risk factor for diabetic patients suffering from cervical atherosclerosis.