子宫内膜癌合并子宫内膜异位症或子宫肌瘤的临床分析

目的:分析子宫内膜癌合并子宫内膜异位症、或子宫肌瘤患者的临床病理特征,探讨可能存在的内在关系。方法:回顾性分析1998-2007年间温州医学院附属第一医院132例子宫内膜癌患者中合并子宫内膜异位症13例(A组、9.8%)、或合并子宫肌瘤21例(B组、15.9%)的临床资料,随机抽取同期单纯性子宫内膜癌患者20例做对照(C组)。结果:A、B组的手术-病理分期、肿瘤组织病理分级分别与C组比较,有非常显著性差异(P<0.005),而A、B组间的比较则无差异(P>0.05)。结论:子宫内膜癌合并子宫内膜异位症/子宫肌瘤多属雌激素依赖性肿瘤,组织分化好,肌层浸润浅,预后较好。单纯性子宫内膜癌多为非雌激素依赖性肿瘤,预后较差。

Clinical Analysis of Endometrial Cancer Coexisting with Endometriosis or Hysteromyoma

Objective: To analyze the clinical characteristic of patients of endometrial cancer coexisting with endometriosis or hysteromyoma,and discuss the possible relationship between them.Methods: The clinical data of endometrial cancer coexisting with endometriosis(group A,n=13) or hysteromyoma(group B,n=21) were retrospectively analyzed,and were compared with that of single endometrial cancer as control group(group C,n=20).Results: The difference in clinic-pathologic and tumor histological grades was significant(P<0.005) between group A and C,or between group B and C,while no difference was found between group A and B.Conclusion: The atypical hyperplasia coexisting with endometriosis or hysteromyoma mostly belongs to estrogen-dependent tumors with well differentiation,shallow myometrial invasion and better prognosis.While single EC mostly belongs to non-estrogen-dependent tumors with poor prognosis.