| S100蛋白在乳腺癌中的表达及意义 |
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| 引用本文： | 王宏,李建辉,李林瑞,王茁. S100蛋白在乳腺癌中的表达及意义[J]. 现代肿瘤医学, 2003, 11(3): 178-180 |
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| 作者姓名： | 王宏 李建辉 李林瑞 王茁 |
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| 作者单位： | 陕西省人民医院肿瘤科,陕西,西安,710068 |
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| 摘 要： | 目的 探讨钙结合蛋白S10 0在乳腺癌组织中的表达及其临床意义 ,研究S10 0蛋白表达与乳腺癌已知预后相关因子C -erbB - 2、ER、PR的关系。方法 采用Elivision二步免疫组织化学法检测 4 6例乳腺癌组织中S10 0蛋白、C -erbB - 2、ER、PR的表达。结果 S10 0蛋白的表达与乳腺癌淋巴结转移及预后有密切关系。S10 0蛋白阳性乳腺癌患者 5年无病生存率显著低于阴性者 (P <0 0 1)。S10 0蛋白在乳腺癌组织中的表达与C -erbB - 2、ER、PR无相关性。结论 S10 0蛋白可以作为预测乳腺癌预后的独立分子指标
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| 关 键 词： | S100蛋白 乳腺癌 钙结合蛋白 肿瘤转移 复发 预后 免疫组织化学 |
| 文章编号： | 1672-4992(2003)03-0178-03 |
| 修稿时间： | 2003-04-20 |
Expression of S100 protein in breast cancer and its clinical significance |
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| WANG Hong,LI Jian-hui,LI Lin-rui,et al.. Expression of S100 protein in breast cancer and its clinical significance[J]. Journal of Modern Oncology, 2003, 11(3): 178-180 |
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| Authors: | WANG Hong LI Jian-hui LI Lin-rui et al. |
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| Affiliation: | WANG Hong,LI Jian-hui,LI Lin-rui,et al. Department of Oncology,People's Hospital of Shaanxi Province,Xian Shannxi 710068,China |
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| Abstract: | objective To investigate the expression of the S100 protein in breast cancer and evaluate its clinical significance. To study the relationship between S100 protein and breast cancer prognosis-associated factor C-erbB2,ER,PR. Methods The expression of S100 protein, C-erbB-2, ER,PR were detected by Elivision immunohistochemistry in 46 breast cancer specimens. Results The expression of S100 protein was related to lymph node status and prognosis in breast cancer. The disease-free survival time of patients with positive expression of S100 protein was significantly shorter than those with negative S100 protein (P< 0.01). No correlation was found between S100 protein and C-erbB-2, ER, PR expression.Conclusion S100 protein could been considered as an independent marker for predicting prognosis in breast cancer. |
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| Keywords: | breast cancer S100 protein immunohistochemistry prognosis |
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