| 抗血吸虫病药物呋喃丙胺顺式异构体的研究 |
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| 引用本文： | 徐懋丽,叶鼎彝,章元琅,雷兴翰. 抗血吸虫病药物呋喃丙胺顺式异构体的研究[J]. 药学学报, 1982, 17(12): 905-908 |
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| 作者姓名： | 徐懋丽 叶鼎彝 章元琅 雷兴翰 |
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| 作者单位： | 上海医药工业研究院(徐懋丽，叶鼎彝，章元琅)，上海医药工业研究院(雷兴翰) |
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| 摘 要： | 呋喃丙胺顺式异构体的合成,系按文献方法制备顺式β-(5-硝基-2-呋喃)-丙烯酸,然后于低温下与异丙胺经混合酸酐法,氨化为顺式与反式两种酰胺的混合物,再经分离获得顺式异构体。实验动物药理结果证明其生物活性与反式异构体相似。
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| 关 键 词： | 抗血吸虫病药 顺式呋喃丙胺异构体 顺式β-(5-硝基-2-呋喃)-丙烯酰异丙胺 |
| 收稿时间： | 1981-10-13 |
THE CIS-ISOMER OF ANTISHISTOSOMAL DRUG FURAPROMIDE |
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| XU Mao-li,YE Ding-yi,ZHANG Yuan-lang and LEI Xing-han. THE CIS-ISOMER OF ANTISHISTOSOMAL DRUG FURAPROMIDE[J]. Acta pharmaceutica Sinica, 1982, 17(12): 905-908 |
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| Authors: | XU Mao-li YE Ding-yi ZHANG Yuan-lang LEI Xing-han |
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| Affiliation: | Shanghai Institute of Pharmaceutical Industrial Research |
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| Abstract: | Nitration of cis-β-(2-furyl) acrylic acid afforded the corresponding cis-β-(5-nitro-furyl), acrylic acid. It was readily converted to cis-β-(5-nitro-2-furyl)-N-isopropyl-acrylamide by amination with isopropylamine through the mixed anhydride method.The biological activity of this cis-isomer was examined in laboratory animals against experimental schistosomiasis and was shown to possess activity similar to that already reported for the trans-isomer. |
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| Keywords: | Furapromide cis-isomer cis-β-(5-Nitro-2-furyl)-N-isopropylacrylamide Antischistosomal drug |
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