Age-related differences in neural activities during risk taking as revealed by functional MRI |
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| Authors: | Lee, Tatia M. C. Leung, Ada W. S. Fox, Peter T. Gao, Jia-Hong Chan, Chetwyn C. H. |
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| Affiliation: | 1Laboratory of Neuropsychology, 2Laboratory of Cognitive and Affective Neuroscience, The University of Hong Kong, 3Laboratory of Applied Cognitive Neuroscience, The Hong Kong Polytechnic University, Hong Kong, China, 4Research Imaging Center, University of Texas Health Science Center at San Antonio, 5Department of Radiology, The University of Chicago, USA |
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| Abstract: | Previous research has clearly documented that risky decisionmaking is different in young and older adults. Yet, there hasbeen a relative dearth of research that seeks to understandsuch age-related changes in the neural activities associatedwith risk taking. To address this research issue, 21 men (12young men, mean age 29.9 ± 6.2 years and 9 older men,mean age 65.2 ± 4.2 years) performed a risky-gains taskwhile their brain activities were monitored by an fMRI scanner.The older adults, relative to their younger peers, presentedwith contralateral prefrontal activity, particularly at theorbitofrontal cortex. Furthermore, stronger activation of theright insula was observed for the older-aged participants comparedto the younger-aged adults. The findings of this study are consistentwith the a priori speculations established in accordance withthe HAROLD model as well as previous findings. Findings of thisstudy suggest that when making risky decisions, there may bepossible neuropsychological mechanisms underlying the changein impulsive and risk-taking behaviors during the course ofnatural ageing. |
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| Keywords: | risk taking ageing insula orbitofrontal cortex prefrontal cortex neuroimaging |
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