急性冠脉综合征患者血清脂联素与高敏C反应蛋白的关系

目的:探讨急性冠状动脉综合征(ACS)患者血清脂联素与高敏C反应蛋白(hsCRP)的关系.方法:收集行冠状动脉造影术的冠心病患者90例,其中急性心肌梗死(AMI)41例,不稳定性心绞痛(UAP)27例;稳定性心绞痛(SAP)22例,健康对照组20例.采用酶联免疫吸附法(ELISA)测定血清脂联素,采用免疫散射比浊法测定hsCRP.结果:ACS组血清脂联素浓度显著低于SAP组(P＜0.05)和对照组(P＜0.01),hsCRP浓度显著高于SAP组(P＜0.05)和对照组(P＜0.01),且ACS组血清脂联素与hsCRP呈负相关(r=-0.33,P＜0.05).结论:脂联素具有抗炎、抗动脉粥样硬化的保护作用,对ACS的发生和发展有一定的预测价值.

The relationship between serum adiponectin and high sensitivity C- reactive protein in patients with acute coronary syndrome

Objective:To investigate the relationship between serum adiponectin and high sensitivity C - reactive protein( hsCRP) in patients with acute coronary syndrome ACS). Methods; Serum adiponectin were measured by enzyme linked immunosorbent assay in patients with acute myocardial infarction(n =41 ) .unstable angina pectoris(n = 27) , stable angina pectoris(n =22) and control group (n =20) . Their serum hsCRP were measured by scatter velocity turbidimethy. All subjects were confirmed by coronary angiography. Results ; Serum adiponectin concentrations in ACS group were significantly lower than those in SAP group) P <0. 05 ) and control group (P<0.01 ) ,accompanied with higher hsCRP ( P < 0. 05 ,P < 0. 01 ) . Serum adiponectin concentrations were correlated negatively with hsCRP ( r =- 0. 33 , P < 0. 05 ). Conculusion; Adiponectin have anti - inflammatory and anti - atherogenic properties, which may play a predictive value for the origin and development of ACS.