大剂量赤芍治疗重症急性胰腺炎疗效观察

目的]探讨大剂量赤芍治疗早期重症急性胰腺炎(SAP)的临床疗效。方法]将符合SAP诊断标准的52例患者随机分成2组,对照组24例应用常规西医治疗方法(包括:加强监护、禁食、胃肠减压、生长抑素、抗感染等);治疗组28例在常规治疗的基础上应用大剂量赤芍煎剂,予胃管内注入。观察2组腹痛、发热、恶心呕吐症状消失的时间,血淀粉酶、白细胞、血钙、血糖恢复正常的时间及并发症的发生率。结果]治疗组腹痛、发热、恶心呕吐症状消失时间及血淀粉酶、白细胞、血糖恢复正常时间均快于对照组(均P<0.05);2组血钙恢复正常时间比较,差异无统计学意义(P>0.05);治疗组并发症的发生率低于对照组(P<0.05)。结论]早期应用大剂量赤芍治疗SAP,可尽快改善患者的症状和实验室指标,明显减少并发症的发生。

Clinical study of high dose red peony root decoction in treating severe acute pancreatitis

Objective]To observe the therapeutic effect of red peony root decoction(RPRD) in treating severe acute pancreatitis(SAP).Methods]Fifty two patients with SAP were randomly divided into two groups.The control group(n=24) was treated with routine treatment(intensive care,fasting,gastrointestinal decompression,somatostatin,antibiotics).The treatment group(n=28) was treated with RPRD and routine treatment.Signs(abdominal pain,fever,nausea and vomiting) and serum biochemical criteria(amylase,white blood cell,blood glucose and blood calcium),complications and mortality were observed.Results] The treatment group alleviated signs rapidly,compared with the control group(P<0.05).The level of amylase,white blood cell and blood glucose quickly recovered(P<0.05).The complication incidence rate in the treatment group was lower than that in the control group(P<0.05).There was no statistic difference as to the recovering time of blood calcium between the treatment group and the control group(P>0.05).Conclusion ]Treating SAP with RPRD in early stage may quickly improve signs and serum biochemical criteria,and reduce the complication incidence rate.