| 复方戊酸雌二醇片的溶出度研究 |
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| 引用本文： | 叶金翠,姜丽霞,陈国神. 复方戊酸雌二醇片的溶出度研究[J]. 中国现代应用药学, 2003, 20(2): 140-141 |
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| 作者姓名： | 叶金翠 姜丽霞 陈国神 |
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| 作者单位： | 浙江省医学科学院药物所,浙江,杭州,310013 |
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| 摘 要： | 目的 进行复方戊酸雌二醇片溶出度的方法学研究。方法 采用桨法，以0．25％十二烷基硫酸钠的磷酸盐缓冲波(pH7.3)为溶出介质，用高效液相色谱法测定溶出度。结果 本法的平均回收率高，产品的溶出度均一性好，与进口品溶出度曲线相近。结论 本法适用于该制剂的溶出度质量控制。
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| 关 键 词： | 复方戊酸雌二醇片 更年期综合症 溶出度 十二烷基硫酸钠 高效液相色谱法 |
| 文章编号： | 1007-7693(2003)02-0140-02 |
Study on the Dissolution of Compound Estradiol Valerate Tablets |
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| YE Jin-cui,JIANG Li-xi,CHEN Guo-shen. Study on the Dissolution of Compound Estradiol Valerate Tablets[J]. The Chinese Journal of Modern Applied Pharmacy, 2003, 20(2): 140-141 |
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| Authors: | YE Jin-cui JIANG Li-xi CHEN Guo-shen |
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| Abstract: | OBJECTIVE To study the dissolution methodology of compound estradiol valerate tablets. METHOD Using 0.25% sodium lauryl sulphate in phosphate buffer (pH=7.3) as medium and samples were determined by HPLC. RESULTS The percentage of EV and NET dissolved from the tablet is not less than 65% and 80% at 60 minutes respectively. The profile of dissolution has a good uniformity and closed to that of the imported products. CONCLUSION The method is applicable to the quality control of the tablets. |
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| Keywords: | compound estradiol valerate tablets dissolution |
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