Trace elemental imaging of coralline hydroxyapatite by laser‐ablation inductively coupled plasma–mass spectroscopy |
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| Authors: | J. Chou C. Austin P. Doble B. Ben‐Nissan B. Milthorpe |
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| Affiliation: | 1. School of Medical and Molecular Bioscience, University of Technology Sydney, , Broadway, NSW, Australia;2. Department of Chemistry and Forensic Science, University of Technology Sydney, , Broadway, NSW, Australia;3. Faculty of Science, University of Technology Sydney, , Broadway, NSW, Australia |
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| Abstract: | The determination of trace element concentrations, as well as their distribution in different biomaterials aimed for clinical applications, is a challenging task in both the areas of biological and materials research. In this research, LA–ICP–MS was employed for image mapping of the trace element distribution in a hydrothermally converted coralline hydroxyapatite material aimed for tissue‐scaffolding applications. Quantification using synthetic matrix‐matched standards was successfully applied for the determination and distribution of elements of interest, Sr and Mg, that influences the mechanical and biological properties of hydroxyapatite‐based bone graft materials. The results showed that the instrument can successfully analyse trace elements and a relatively good image can be produced that identifies their distribution. The LA–ICP–MS method can provide an easy and effective tool, in the field of biomaterials with respect to distribution of trace elements, to better understand tissue–implant interactions, and will open up a new window for in vitro and in vivo analysis and imaging of different tissues and structures. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | trace elements hydroxyapatite laser ablation elemental imaging |
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