| 实验梗阻性胆汁郁积早期肝脏细胞反应的超微结构研究 |
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| 引用本文： | 洪明理,李云生,付治锋,任家强,童洁,李非,苏建新.实验梗阻性胆汁郁积早期肝脏细胞反应的超微结构研究[J].中国医学影像学杂志,1994,2(1):29-32. |
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| 作者姓名： | 洪明理 李云生 付治锋 任家强 童洁 李非 苏建新 |
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| 作者单位： | 北京友谊医院，北京市临床医学研究所，北京宣武医院外科 |
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| 摘 要： | 大鼠胆总管结扎术后１至１４天，其肝组织在光学显微镜和透射电镜下观察，发现肝细胞散在性萎缩、变性直至坏死；周围可见肝细胞分裂相，小胆管样上皮细胞在汇管区周围增生并向小叶内发展。本文探讨了胆道梗阻导致肝细胞损伤、坏死的机理，小胆管样上皮细胞增生与肝细胞损伤、坏死的关系及其在肝硬化发生中的作用。
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| 关 键 词： | 胆总管结扎 肝细胞坏死 小胆管样上皮细胞增生 肝硬化 |
Ultrastructural Study on Hepatic Cells Response During Early Stage in ExperimentalObstructive Cholestasis |
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| Hong Mingli, Li Yunsheng,Fu Zhifeng, Ren Jiaqiang, Tong Jie,Li fei,Su Jianxin.Ultrastructural Study on Hepatic Cells Response During Early Stage in ExperimentalObstructive Cholestasis[J].Chinese Journal of Medical Imaging,1994,2(1):29-32. |
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| Authors: | Hong Mingli Li Yunsheng Fu Zhifeng Ren Jiaqiang Tong Jie Li fei Su Jianxin |
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| Abstract: | The morphological changes of liver were observed in rats whose common bile ducthad been irreversibly ligated for 1 to 14 days by light and electron microscope. It was foundthat some hepatocytes appeared atrophy,degeneration and necrosis, hepatocytic mitosis wasseen around the damaged cells, bile ductuloid epithelial cells proliferated at the periportal areasand developed into lobule.The pathogenesis of hepatocyte damage and necrosis caused by the ligation of common blieduct has been discussed, it included the relationship between the proliferation of bile ductuloidepithelial cells and the damage and necrosis of hepatocytes, and the significance of the bileductuloid epithelial cells in the development of liver cirrhosis. |
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| Keywords: | common bile duct ligate hepatocyte necrosis bile ductuloid epithelial cellproliferate liver cirrhosis |
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